Induction of c-fos and junB mRNA following in vivo brain irradiation

Ji Hong Hong*, Chi Shiun Chiang, Ji Rong Sun, H. Rodney Withers, William H. McBride

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

23 引文 斯高帕斯(Scopus)

摘要

Although radiotherapy is a front line treatment for brain tumors, little is known about the in vivo molecular responses of brain to irradiation. In this study, expression of c-fos, c-jun and junB immediate-early genes were followed in mouse brain after irradiation. C-fos and junB, but not c-jun, mRNA was induced within 15 min in unanesthetized irradiated mice. Induction was transient and lasted < 4 h. The response was dose-dependent with increases in c-fos and junB mRNA levels after dose of ≤ 2 and 7 Gy, respectively. Anesthesia of mice with pentobarbitol delayed the increases in mRNA expression and the response was attenuated. Pre-treatment of mice with dexamethasone, in a schedule which suppressed acute-phase gene expression after brain irradiation, did not significantly change c-fos and junB induction. Our results show that c-fos and junB responses occur in the brain in response to irradiation and that they can be modified by pentobarbital treatment but suggest that there is no direct correlation between the level of mRNA expression and later expression of cytokines or other acute-phase response genes.

原文英語
頁(從 - 到)223-228
頁數6
期刊Molecular Brain Research
48
發行號2
DOIs
出版狀態已出版 - 09 1997
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