Inflammation Modulatory Phorbol Esters from the Seeds of Aquilaria malaccensis

Vitthal D. Wagh, Michal Korinek, I. Wen Lo, Yu Ming Hsu, Shu Li Chen, Hsue Yin Hsu, Tsong Long Hwang, Yang Chang Wu, Bing Hung Chen, Yuan Bin Cheng*, Fang Rong Chang

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

The tree Aquilaria malaccensis is a valuable source of agarwood, which is used in herbal medicinal preparations. Phytochemical research on A. malaccensis seeds has led to the isolation of four new phorbol esters (1-4), two known phorbol esters (5, isolated from Nature for the first time, and 6), and two known glycerides (7 and 8). The structures of these isolates were elucidated by means of spectroscopic data interpretation. The inflammation-modulatory activities of the isolates on elastase release and superoxide anion generation in human neutrophils were evaluated. Interestingly, phorbol esters 1, 5, and 6 showed potent inhibitory activity on elastase release in human neutrophils, with IC50 values of 2.7, 0.8, and 2.1 μM, respectively. All isolated phorbol esters exerted enhancing activity on superoxide anion generation. The results indicated that phorbol esters may play a bilateral modulatory role in the processes of inflammation. In addition, the compounds were evaluated for their cytotoxic properties against HepG2 (hepatoma), MDA-MB-231 (breast), and A549 (lung) cancer cells, but all compounds were inactive for all cell lines used (IC50 > 10 μM).

原文英語
頁(從 - 到)1421-1427
頁數7
期刊Journal of Natural Products
80
發行號5
DOIs
出版狀態已出版 - 26 05 2017

文獻附註

Publisher Copyright:
© 2017 The American Chemical Society and American Society of Pharmacognosy.

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