Interactions between guanabenz and clonidine in their cardiovascular effects in the rat

B. T. Ong*, Samuel H.H. Chan

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

14 引文 斯高帕斯(Scopus)

摘要

In Sprague-Dawley rats anesthetized with pentobarbital sodium (40 mg/kg, i.p.), guanabenz and clonidine exhibited mutually interactive effects on the cardiovascular system. Pretreatment with either antihypertensive agent (5 or 10 μg/kg, i.v.) significantly potentiated both the degree and duration of the initial elevation in arterial pressure and cardiac contractility promoted by the other compound (10 μg/kg, i.v.). On the other hand, discernible antagonization existed mutually for their delayed hypotensive, as well as negative inotropic and chronotropic actions. Furthermore, these circulatory changes displayed comparable trends under parallel drug interaction schemes, as revealed by correlation coefficient evaluations. It is possible that guanabenz and clonidine may share a common mechanism(s) in their cardiovascular actions.

原文英語
頁(從 - 到)105-112
頁數8
期刊Experimental Neurology
86
發行號1
DOIs
出版狀態已出版 - 10 1984
對外發佈

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