Interleukin‐13 alters the activation state of murine macrophages in vitro: Comparison with interleukin‐4 and interferon‐γ

Anthony G. Doyle, Georges Herbein, Luis J. Montaner, Adrian J. Minty, Daniel Caput, Pascual Ferrara, Siamon Gordon*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

258 引文 斯高帕斯(Scopus)

摘要

Interleukin (IL)‐13 is a newly described cytokine expressed by activated lymphocytes. We examined the effects of the murine recombinant cytokine on the phenotype and activation status of elicited peritoneal macrophages (Mϕ), concentrating on activities which are known to be modulated by interferon‐γ and IL‐4. IL‐13 markedly suppressed nitric oxide release and to a lesser extent secretion of the pro‐inflammatory cytokine tumor necrosis factor‐α. However, antimicrobial capacity was not completely jeopardized as the respiratory burst was unaffected, and indeed the enhanced expression of Mϕ mannose receptor and major histocompatibility class II, and regulation of sialoadhesin, the Mϕ sialic acid‐specific receptor involved in hemopoietic and lymphoid interactions, suggest that these cells are not simply deactivated, but primed for an active role in immune and inflammatory responses. These activities closely mimic those of IL‐4, but mediation of the effects by IL‐4 was discounted by the use of a neutralizing monoclonal antibody. Thus, IL‐13, like IL‐4, is a cytokine which has complex effects on Mϕ behavior, inducing activities characteristic of both activation and deactivation.

原文英語
頁(從 - 到)1441-1445
頁數5
期刊European Journal of Immunology
24
發行號6
DOIs
出版狀態已出版 - 06 1994
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