Intrarenal artery autologous mesenchymal stem cell injection for treatment of chronic glomerulonephritis in cat

Chronic glomerulonephritis is a major cause of morbidity and mortality in feline chronic kidney diseases. Mesenchymal stem cells are multipotent stem cells found in the stroma of bone marrow, adipose tissue and umbilical cord. Mesenchymal stem cells can be induced to differentiate into a wide array of cells types including osteoblasts, chondrocytes, myocytes, adipocytes, endothelium and neuronal cells. The effects of mesenchymal stem cell therapy have been investigated in rodent chronic renal failure models including genetic disease, glomerulo-nephritis and experimentally-induced chronic kidney diseases. The purpose of this study was to assess the feasibility of intra-renal artery mesenchymal stem cells transfer in cat with chronic glomerulonephritis. Researchers, hypothesized that mesenchymal stem cells could be safely administered to cats with chronic glomerulo-nephritis. Intra-renal artery mesenchymal stem cells injection would improve the function of the injected kidney. This clinical result showed the optimal direction that the patient demonstrated blood urea nitrogen and creatinine improvement after intra-renal artery mesenchymal stem cells transfer.