摘要
The laser treatment is an ideal option to conduct a surgical resection since it enables to provide higher accuracy and to cause less damage when targeting invariant tissue areas. Compared to traditional mechanical or chemical treatment modalities, it can shrink or destroy cancer cells using a narrow, focused light beam without harming normal tissue nearby. Laser speckle contrast image (LSCI) is a powerful technology that is able to capture dynamic changes of backscattered light, and then, convert it to relative flow using speckle contrast analysis. When the coherent light illuminates biological tissue, random interference patterns will be received at the detector. If the particles are moving, patterns will result in fluctuation as known as speckle patterns. By setting the exposure time equal to or longer than the speckle fluctuation duration, such intensity fluctuation can be recorded, forming the speckle image. Since red blood cell is the primary moving particles in vessels, the blurring can be related to flow information. Previous reports have also indicated that the autocorrelation time is inversely related to the blood flow velocity. As a result, microvasculature and blood flow data can be represented by analyzing the speckle variance of biological tissue spatially and temporarily. In this study, we propose to use LSCI to in vivo investigate the induced thermal effect by laser illumination, and the difference in the thermal effect caused by the CW and pulsed lasers will be compared. Finally, the treatment outcomes on brain tumor will be also compared.
原文 | 英語 |
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主出版物標題 | Biomedical Imaging and Sensing Conference 2021 |
編輯 | Toyohiko Yatagai, Yoshihisa Aizu, Osamu Matoba, Yasuhiro Awatsuji, Yuan Luo |
發行者 | SPIE |
ISBN(電子) | 9781510647190 |
DOIs | |
出版狀態 | 已出版 - 2021 |
事件 | Biomedical Imaging and Sensing Conference 2021 - Virtual, Online, 日本 持續時間: 20 04 2021 → 22 04 2021 |
出版系列
名字 | Proceedings of SPIE - The International Society for Optical Engineering |
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卷 | 11925 |
ISSN(列印) | 0277-786X |
ISSN(電子) | 1996-756X |
Conference
Conference | Biomedical Imaging and Sensing Conference 2021 |
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國家/地區 | 日本 |
城市 | Virtual, Online |
期間 | 20/04/21 → 22/04/21 |
文獻附註
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