Involvement of locus coeruleus and noradrenergic neurotransmission in fentanyl-induced muscular rigidity in the rat

Ping Wing Lui, Tak Yu Lee, Samuel H.H. Chan*

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52 引文 斯高帕斯(Scopus)

摘要

Whereas muscular rigidity is a well-known side effect that is associated with high-dose fentanyl anesthesia, a paucity of information exists with regard to its underlying mechanism(s). We investigated in this study the possible engagement of locus coeruleus of the pons in this phenomenon, using male Sprague-Dawley rats anesthetized with ketamine. Under proper control of respiration, body temperature and endtidal CO2, intravenous administration of fentanyl (50 or 100 μg/kg) consistently promoted an increase in electromyographic activity recorded from the gastrocnemius and abdominal rectus muscles. Such an induced muscular rigidity by the narcotic agent was significantly antagonzied or even reduced by prior electrolytic lesions of the locus coeruleus or pretreatment with the α-adrenoceptor blocker, prazosin. Microinjection of fentanyl (2.5 μg/50 nl) directly into this pontine nucleus, on the other hand, elicited discernible electromyographic excitation. It is speculated that the induction of muscular rigidity by fentanyl may involve the coerulospinal noradrenergic fibers to the spinal motoneurons.

原文英語
頁(從 - 到)114-119
頁數6
期刊Neuroscience Letters
96
發行號1
DOIs
出版狀態已出版 - 02 01 1989
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