Ionone derivatives from the mycelium of Phellinus linteus and the inhibitory effect on activated rat hepatic stellate cells

Shiow Chyn Huang; Ping Chung Kuo; Hsin Yi Hung; Tai Long Pan; Fu An Chen; Tian Shung Wu

doi:10.3390/ijms17050681

Ionone derivatives from the mycelium of Phellinus linteus and the inhibitory effect on activated rat hepatic stellate cells

Shiow Chyn Huang
, Ping Chung Kuo
, Hsin Yi Hung
, Tai Long Pan
, Fu An Chen
, Tian Shung Wu^*

^*此作品的通信作者

中醫學系(含學士班、天然藥物、傳統中醫藥碩士班)

Chia Nan University of Pharmacy and Science
National Cheng Kung University
Tajen University

研究成果: 期刊稿件 › 快報 › 同行評審

18 引文斯高帕斯（Scopus）

摘要

Three new γ-ionylideneacetic acid derivatives, phellinulins A–C (1–3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.

原文	英語
文章編號	681
期刊	International Journal of Molecular Sciences
卷	17
發行號	5
DOIs	https://doi.org/10.3390/ijms17050681
出版狀態	已出版 - 06 05 2016

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

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@article{5a7dfa57163b41969b7d735faeeb26bd,

title = "Ionone derivatives from the mycelium of Phellinus linteus and the inhibitory effect on activated rat hepatic stellate cells",

abstract = "Three new γ-ionylideneacetic acid derivatives, phellinulins A{\textendash}C (1{\textendash}3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.",

keywords = "Fungus, Hepatic fibrosis, Ionone, Phellinulin, Phellinus linteus",

author = "Huang, \{Shiow Chyn\} and Kuo, \{Ping Chung\} and Hung, \{Hsin Yi\} and Pan, \{Tai Long\} and Chen, \{Fu An\} and Wu, \{Tian Shung\}",

note = "Publisher Copyright: {\textcopyright} 2016 by the authors; licensee MDPI, Basel, Switzerland.",

year = "2016",

month = may,

day = "6",

doi = "10.3390/ijms17050681",

language = "英语",

volume = "17",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

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TY - JOUR

T1 - Ionone derivatives from the mycelium of Phellinus linteus and the inhibitory effect on activated rat hepatic stellate cells

AU - Huang, Shiow Chyn

AU - Kuo, Ping Chung

AU - Hung, Hsin Yi

AU - Pan, Tai Long

AU - Chen, Fu An

AU - Wu, Tian Shung

PY - 2016/5/6

Y1 - 2016/5/6

N2 - Three new γ-ionylideneacetic acid derivatives, phellinulins A–C (1–3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.

AB - Three new γ-ionylideneacetic acid derivatives, phellinulins A–C (1–3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.

KW - Fungus

KW - Hepatic fibrosis

KW - Ionone

KW - Phellinulin

KW - Phellinus linteus

UR - https://www.scopus.com/pages/publications/84966440371

U2 - 10.3390/ijms17050681

DO - 10.3390/ijms17050681

M3 - 快报

C2 - 27164091

AN - SCOPUS:84966440371

SN - 1661-6596

VL - 17

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 5

M1 - 681

ER -

Ionone derivatives from the mycelium of Phellinus linteus and the inhibitory effect on activated rat hepatic stellate cells

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