Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors

Iou Jiun Kang; Li Wen Wang; Tsu An Hsu; Andrew Yueh; Chung Chi Lee; Yen Chun Lee; Ching Yin Lee; Yu Sheng Chao; Shin Ru Shih; Jyh Haur Chern

doi:10.1016/j.bmcl.2011.02.037

Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors

Iou Jiun Kang, Li Wen Wang, Tsu An Hsu, Andrew Yueh, Chung Chi Lee, Yen Chun Lee, Ching Yin Lee, Yu Sheng Chao, Shin Ru Shih^*, Jyh Haur Chern

^*此作品的通信作者

醫學生物技術暨檢驗學系(含學碩博士班)

研究成果: 期刊稿件 › 文章 › 同行評審

66 引文斯高帕斯（Scopus）

摘要

A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.

原文	英語
頁（從 - 到）	1948-1952
頁數	5
期刊	Bioorganic and Medicinal Chemistry Letters
卷	21
發行號	7
DOIs	https://doi.org/10.1016/j.bmcl.2011.02.037
出版狀態	已出版 - 01 04 2011

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10.1016/j.bmcl.2011.02.037

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abstract = "A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.",

keywords = "HSV-1, HSV-2, Herpes simplex virus",

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AU - Kang, Iou Jiun

AU - Wang, Li Wen

AU - Hsu, Tsu An

AU - Yueh, Andrew

AU - Lee, Chung Chi

AU - Lee, Yen Chun

AU - Lee, Ching Yin

AU - Chao, Yu Sheng

AU - Shih, Shin Ru

AU - Chern, Jyh Haur

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N2 - A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.

AB - A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.

KW - HSV-1

KW - HSV-2

KW - Herpes simplex virus

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AN - SCOPUS:79952484386

SN - 0960-894X

VL - 21

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors

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