Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart

Chen Leng Cai, Xingqun Liang, Yunqing Shi, Po Hsien Chu, Samuel L. Pfaff, Ju Chen, Sylvia Evans*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

1346 引文 斯高帕斯(Scopus)

摘要

Hearts of mice lacking Isl1, a LIM homeodomain transcription factor, are completely missing the outflow tract, right ventricle, and much of the atria. isl1 expression and lineage tracing of isl1 -expressing progenitors demonstrate that Isl1 is a marker for a distinct population of undifferentiated cardiac progenitors that give rise to the cardiac segments missing in isl1 mutants. Isl1 function is required for these progenitors to contribute to the heart. In isl1 mutants, isl1-expressing progenitors are progressively reduced in number, and FGF and BMP growth factors are downregulated. Our studies define two sets of cardiogenic precursors, one of which expresses and requires Isl1 and the other of which does not. Our results have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells.

原文英語
頁(從 - 到)877-889
頁數13
期刊Developmental Cell
5
發行號6
DOIs
出版狀態已出版 - 12 2003
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