LncRNA H19 polymorphisms associated with the risk of OSCC in Chinese population

OBJECTIVE: H19, a maternally expressed imprinted gene transcribing a long noncoding RNA, has previously been reported to be involved in tumorigenesis and cancer progression. The relationship between H19 and susceptibility of multiple tumors is inconsistent, and currently there is a lack of association of H19 with the risk of oral squamous cell carcinoma (OSCC). The objective to design this research is to investigate and discuss the association of H19 with susceptibility to oral squamous cell carcinoma in Chinese population.

PATIENTS AND METHODS: In this research, Illumina Infinium Human Exome BeadChip technology was used for genetic tests in 362 patients who were pathologically diagnosed with new-onset OSCC and 741 healthy controls with matching gender and age, so as to analyze the association of H19 gene polymorphism sites (rs2735971, rs217727, rs2839698 and rs3024270) with susceptibility of OSCC.

RESULTS: The results of this research showed that rs217727 [Additive model: adjusted odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.02-1.46; AA vs. GG: Adjusted OR = 1.20, 95% CI = 1.00-1.44] was related to the susceptibility of oral squamous cell carcinoma. It was not found in the results that the other three sites were associated with the susceptibility of oral squamous cell carcinoma.

CONCLUSIONS: It is indicated in this research that rs217727 is statistically correlated with the susceptibility of OSCC.