Long-term antibacterial performances of biodegradable polylactic acid materials with direct absorption of antibiotic agents

Chien Hao Chen, Yuan Yuan Yao, Hao Che Tang, Tung Yi Lin, Dave W. Chen*, Kong Wei Cheng

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

In this study, polylactic acid (PLA) disks with antibacterial performances were prepared using 3D printing technology combined with direct adsorption of the antibiotic agents in solution baths. The effects of the layer thicknesses for the building of the 3D printing PLA disks and the amounts of antibiotic agents absorbed onto the sample surfaces on their antibacterial activities were investigated. The antibiotic agent release profiles from the samples surface into the buffer solution show that the antibacterial performances of these samples can reach up to 28 days. With a decrease in the concentration of antibiotic agent in the solution bath, the amount of antibiotic agent adsorbed on the sample surfaces also decreases, but their antibacterial performances can still maintain at least 7 days. In the bioactivity tests of the various organisms, the release amount of antibiotic agent from the sample can inhibit E. coli and S. aureus for over 80% up to 28 days. In the antibacterial activity tests, a PLA disk with suitable antibiotic agents covering its surface has a good inhibitory effect on the growth ability of S. aureus of less than 50% in six hours.

原文英語
頁(從 - 到)16223-16231
頁數9
期刊RSC Advances
8
發行號29
DOIs
出版狀態已出版 - 2018

文獻附註

Publisher Copyright:
© 2018 The Royal Society of Chemistry.

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