Macrophage phenotype in tumours

Hsi Hsien Lin; Siamon Gordon

doi:10.1007/978-1-4614-0662-4_1

Macrophage phenotype in tumours

Hsi Hsien Lin
, Siamon Gordon^*

^*此作品的通信作者

微生物及免疫學科

University of Oxford

研究成果: 圖書/報告稿件的類型 › 章節 › 同行評審

1 引文斯高帕斯（Scopus）

摘要

Macrophages are often present in tumours, display considerable heterogeneity in phenotype, and contribute trophic, tumour-promoting functions that favour clonal emergence, growth and spread of malignant cells, as well as contributing to host tolerance and stromal reactions. Membrane glycoproteins provide antigenic markers, serve as receptors for tumour-derived ligands, and regulate macrophage-tumour interactions. We review selected aspects of macrophage phenotypic heterogeneity, with special reference to novel markers such as the EGF-TM7 family of myeloid differentiation antigens. Improved characterisation of macrophage plasticity may make it possible to manipulate macrophage effector functions to the advantage of the host.

原文	英語
主出版物標題	Tumour-Associated Macrophages
發行者	Springer New York
頁面	3-16
頁數	14
ISBN（電子）	9781461406624
ISBN（列印）	1461406617, 9781461406617
DOIs	https://doi.org/10.1007/978-1-4614-0662-4_1
出版狀態	已出版 - 01 05 2011

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© 2012 Springer Science+Business Media, LLC. All rights reserved.

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Macrophage phenotype in tumours

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