Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma

Hsuan Jen Shih; Ming Chung Kuo; Tung Liang Lin; Hsiao Wen Kao; Jin Hou Wu; Yu Shin Hung; Che Wei Ou; Yi Jiun Su; Hung Chang

doi:10.3892/ol.2023.14190

Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma

Hsuan Jen Shih
, Ming Chung Kuo
, Tung Liang Lin
, Hsiao Wen Kao
, Jin Hou Wu
, Yu Shin Hung
, Che Wei Ou
, Yi Jiun Su
, Hung Chang^*

^*此作品的通信作者

Chang Gung Memorial Hospital
Chang Gung University

研究成果: 期刊稿件 › 文章 › 同行評審

3 引文斯高帕斯（Scopus）

摘要

The effective prognostic factors for primary mediastinal large B-cell lymphoma (PMLBCL) vary among published studies. The aim of the present study was to explore the factors influencing the overall survival (OS) and progression-free survival (PFS) of patients with PMLBCL at a single institute in Taiwan. This retrospective study was conducted to analyze the prognostic impact of age, sex, disease stage, International Prognostic Index (IPI) score, treatment modality and initial response. A total of 72 patients with a median age of 28 years were included in the study. The mean OS and PFS were 171.40 and 159.77 months, respectively. Female sex, age ≤60 years, receiving radiotherapy (RT) and achieving a complete response were found to be associated with a significantly improved OS and PFS.

原文	英語
文章編號	57
期刊	Oncology Letters
卷	27
發行號	2
DOIs	https://doi.org/10.3892/ol.2023.14190
出版狀態	已出版 - 02 2024
對外發佈	是

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title = "Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma",

abstract = "The effective prognostic factors for primary mediastinal large B-cell lymphoma (PMLBCL) vary among published studies. The aim of the present study was to explore the factors influencing the overall survival (OS) and progression-free survival (PFS) of patients with PMLBCL at a single institute in Taiwan. This retrospective study was conducted to analyze the prognostic impact of age, sex, disease stage, International Prognostic Index (IPI) score, treatment modality and initial response. A total of 72 patients with a median age of 28 years were included in the study. The mean OS and PFS were 171.40 and 159.77 months, respectively. Female sex, age ≤60 years, receiving radiotherapy (RT) and achieving a complete response were found to be associated with a significantly improved OS and PFS.",

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author = "Shih, \{Hsuan Jen\} and Kuo, \{Ming Chung\} and Lin, \{Tung Liang\} and Kao, \{Hsiao Wen\} and Wu, \{Jin Hou\} and Hung, \{Yu Shin\} and Ou, \{Che Wei\} and Su, \{Yi Jiun\} and Hung Chang",

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doi = "10.3892/ol.2023.14190",

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AU - Shih, Hsuan Jen

AU - Kuo, Ming Chung

AU - Lin, Tung Liang

AU - Kao, Hsiao Wen

AU - Wu, Jin Hou

AU - Hung, Yu Shin

AU - Ou, Che Wei

AU - Su, Yi Jiun

AU - Chang, Hung

PY - 2024/2

Y1 - 2024/2

N2 - The effective prognostic factors for primary mediastinal large B-cell lymphoma (PMLBCL) vary among published studies. The aim of the present study was to explore the factors influencing the overall survival (OS) and progression-free survival (PFS) of patients with PMLBCL at a single institute in Taiwan. This retrospective study was conducted to analyze the prognostic impact of age, sex, disease stage, International Prognostic Index (IPI) score, treatment modality and initial response. A total of 72 patients with a median age of 28 years were included in the study. The mean OS and PFS were 171.40 and 159.77 months, respectively. Female sex, age ≤60 years, receiving radiotherapy (RT) and achieving a complete response were found to be associated with a significantly improved OS and PFS.

AB - The effective prognostic factors for primary mediastinal large B-cell lymphoma (PMLBCL) vary among published studies. The aim of the present study was to explore the factors influencing the overall survival (OS) and progression-free survival (PFS) of patients with PMLBCL at a single institute in Taiwan. This retrospective study was conducted to analyze the prognostic impact of age, sex, disease stage, International Prognostic Index (IPI) score, treatment modality and initial response. A total of 72 patients with a median age of 28 years were included in the study. The mean OS and PFS were 171.40 and 159.77 months, respectively. Female sex, age ≤60 years, receiving radiotherapy (RT) and achieving a complete response were found to be associated with a significantly improved OS and PFS.

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KW - primary mediastinal large B cell lymphoma

KW - prognosis

KW - sex

UR - https://www.scopus.com/pages/publications/85180592766

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DO - 10.3892/ol.2023.14190

M3 - 文章

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JO - Oncology Letters

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Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma

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UN SDG

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