Maternal High-Fat Diet and Offspring Hypertension

You Lin Tain, Chien Ning Hsu*

*此作品的通信作者

研究成果: 期刊稿件文獻綜述同行評審

15 引文 斯高帕斯(Scopus)

摘要

The incidence of hypertension has increased to epidemic levels in the past decades. Increasing evidence reveals that maternal dietary habits play a crucial role in the development of hypertension in adult offspring. In humans, increased fat consumption has been considered responsible for obesity and associated diseases. Maternal diets rich in saturated fats have been widely employed in animal models to study various adverse offspring outcomes. In this review, we discussed current evidence linking maternal high-fat diet to offspring hypertension. We also provided an in-depth overview of the potential mechanisms underlying hypertension of developmental origins that are programmed by maternal high-fat intake from animal studies. Furthermore, this review also presented an overview of how reprogramming interventions can prevent maternal high-fat-diet-induced hypertension in adult offspring. Overall, recent advances in understanding mechanisms behind programming and reprogramming of maternal high-fat diet on hypertension of developmental origins might provide the answers to curtail this epidemic. Still, more research is needed to translate research findings into practice.

原文英語
文章編號8179
期刊International Journal of Molecular Sciences
23
發行號15
DOIs
出版狀態已出版 - 08 2022

文獻附註

Publisher Copyright:
© 2022 by the authors.

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