MicroRNA-mediated alteration of TET2 interaction network in myeloproliferative neoplasms

Feng Feng Wang*, Lawrence W.C. Chan, S. P. Yip, Benjamin Y.M. Yung

*此作品的通信作者

研究成果: 圖書/報告稿件的類型會議稿件同行評審

1 引文 斯高帕斯(Scopus)

摘要

Myeloproliferative neoplasms (MPNs) constitute a type of proliferative and dysplastic myeloid tumors, which are frequently found in the elderly people. Although some kinds of gene mutations in MPNs have been studied, the biological mechanisms behind this disease are still not very clear. Researchers have found that MPN patients with TET2 mutations have low level of 5hmC. However, they do not give reasons why there is also low level of 5hmC in patients with wild-type TET2. The aim of this study is to investigate into the role of TET2 and its interacting proteins in MPN under the repression by microRNAs. MicroRNAs are short, endogenous, non-coding RNA molecules, which regulate the target genes expression. We hypothesize that microRNAs lead to low level of 5hmC by down-regulating the expression of TET2 and other proteins interacting with TET2 in MPN patients with wild-type TET2, which is similar to the function of TET2 mutations. Bioinformatics tools were performed in this study. There were 11 databases considered, only 3 of which predicted microRNAs binding to TET2. Moreover, 10 proteins were found to be associated with TET2 according to STRING database and their targeting miRNA predictions was compared with that of TET2. The hypothesis can be supported by he predicted simultaneous repression of DNMT-1 and TET2 by miR-152.

原文英語
主出版物標題2011 IEEE 13th International Conference on e-Health Networking, Applications and Services, HEALTHCOM 2011
頁面241-245
頁數5
DOIs
出版狀態已出版 - 2011
對外發佈
事件2011 IEEE 13th International Conference on e-Health Networking, Applications and Services, HEALTHCOM 2011 - Columbia, MO, 美國
持續時間: 13 06 201115 06 2011

出版系列

名字2011 IEEE 13th International Conference on e-Health Networking, Applications and Services, HEALTHCOM 2011

Conference

Conference2011 IEEE 13th International Conference on e-Health Networking, Applications and Services, HEALTHCOM 2011
國家/地區美國
城市Columbia, MO
期間13/06/1115/06/11

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