摘要
Erythema multiforme (EM) an immune-mediated disease categorized into EM minor and EM major, also called Stevens-Johnson syndrome. The presence of mucosal involvement differentiates erythema multiforme major from erythema multiforme minor. Many drugs and agents can induce Stevens-Johnson syndrome. We report a case of Stevens-Johnson syndrome associated with Mycoplasma pneumoniae infection. Lymphopenia with a significant decrease of CD4+ T cell in the blood and predominant CD4+ T cells in the skin vesicular fluid was found. The improvement of lymphopenia was associated with disease recovery. In a retrospective chart review of patients treated in our hospital over the past 3 years, we found that 5 patients with Stevens-Johnson syndrome all had lymphopenia (< 1.5 × 109/L; average 0.99 × 109/L), whereas 13 other patients with erthema multiforme minor demonstrated normal lymphocyte counts (average 3.13 × 109/L), with the exception of one patients with herpes infection showing lymphopenia. There results suggested that an immunopathologenesis involving redistribution of CD4+ T cells might contribute to the development of Stevens-Johnson syndrome. Further studies to investigate the involvement of CD4+ T cells in Stevens-Johnson syndrome may implicate a specific strategy to prevent fatal Steven-Johnson syndrome.
原文 | 英語 |
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頁(從 - 到) | 55-58 |
頁數 | 4 |
期刊 | Journal of the Formosan Medical Association |
卷 | 102 |
發行號 | 1 |
出版狀態 | 已出版 - 01 01 2003 |
對外發佈 | 是 |