Novel G9 rotavirus strains co-circulate in children and pigs, Taiwan

Fang Tzy Wu*, Krisztián Bányai, Baoming Jiang, Luke Tzu Chi Liu, Szilvia Marton, Yhu Chering Huang, Li Min Huang, Ming Hui Liao, Chao A. Hsiung

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

38 引文 斯高帕斯(Scopus)

摘要

Molecular epidemiologic studies collecting information of the spatiotemporal distribution of rotavirus VP7 (G) and VP4 (P) genotypes have shown evidence for the increasing global importance of genotype G9 rotaviruses in humans and pigs. Sequence comparison of the VP7 gene of G9 strains identified different lineages to prevail in the respective host species although some of these lineages appear to be shared among heterologous hosts providing evidence of interspecies transmission events. The majority of these events indicates the pig-To-human spillover, although a reverse route of transmission cannot be excluded either. In this study, new variants of G9 rotaviruses were identified in two children with diarrhea and numerous pigs in Taiwan. Whole genome sequence and phylogenetic analyses of selected strains showed close genetic relationship among porcine and human strains suggesting zoonotic origin of Taiwanese human G9 strains detected in 2014-2015. Although the identified human G9P[19] and G9P[13] rotaviruses represented minority strains, the repeated detection of porcine-like rotavirus strains in Taiwanese children over time justifies the continuation of synchronized strain surveillance in humans and domestic animals.

原文英語
文章編號40731
期刊Scientific Reports
7
DOIs
出版狀態已出版 - 18 01 2017
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