Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring

Wen Ju Chen; Feng Yu Chang; Meng Tsan Tsai

doi:10.1117/12.2573215

Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring

Wen Ju Chen, Feng Yu Chang, Meng Tsan Tsai^*

^*此作品的通信作者

電機工程學系(含學碩博士班及碩士在職專班)

研究成果: 圖書/報告稿件的類型 › 會議稿件 › 同行評審

摘要

In this study, an integrated theranostic system combining a CW laser diode with optical coherence tomography (OCT)/angiography (OCTA) was utilized for tumor identification and treatment monitoring. To examine the effect of laser exposure on tissue scattering characteristics, the OCT backscattering intensities of non-ablated and ablated tissues were analyzed, and the effect on the skin microvasculature produced by laser ablation was quantitatively evaluated. Moreover, the integrated system and the proposed method were implemented for the treatment of skin and brain tumors on the mouse model. The obtained results indicate that the developed laser ablation system can effectively remove tumor tissues with controllable photodamage under OCT/OCTA guidance and that the system cost may be significantly reduced by using the CW laser diode.

原文	英語
主出版物標題	Biomedical Imaging and Sensing Conference 2020
編輯	Toyohiko Yatagai, Yoshihisa Aizu, Osamu Matoba, Yasuhiro Awatsuji, Yuan Luo
發行者	SPIE
ISBN（電子）	9781510638495
DOIs	https://doi.org/10.1117/12.2573215
出版狀態	已出版 - 2020
事件	6th Biomedical Imaging and Sensing Conference - Yokohama, 日本持續時間: 20 04 2020 → 24 04 2020

出版系列

名字	Proceedings of SPIE - The International Society for Optical Engineering
卷	11521
ISSN（列印）	0277-786X
ISSN（電子）	1996-756X

Conference

Conference	6th Biomedical Imaging and Sensing Conference
國家/地區	日本
城市	Yokohama
期間	20/04/20 → 24/04/20

文獻附註

Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

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10.1117/12.2573215

其它文件與鏈接

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引用此

Chen, W. J., Chang, F. Y., & Tsai, M. T. (2020). Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring. 於 T. Yatagai, Y. Aizu, O. Matoba, Y. Awatsuji, & Y. Luo (編輯), Biomedical Imaging and Sensing Conference 2020 文章 1152106 (Proceedings of SPIE - The International Society for Optical Engineering; 卷 11521). SPIE. https://doi.org/10.1117/12.2573215

Chen, Wen Ju ; Chang, Feng Yu ; Tsai, Meng Tsan. / Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring. Biomedical Imaging and Sensing Conference 2020. 編輯 / Toyohiko Yatagai ; Yoshihisa Aizu ; Osamu Matoba ; Yasuhiro Awatsuji ; Yuan Luo. SPIE, 2020. (Proceedings of SPIE - The International Society for Optical Engineering).

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title = "Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring",

abstract = "In this study, an integrated theranostic system combining a CW laser diode with optical coherence tomography (OCT)/angiography (OCTA) was utilized for tumor identification and treatment monitoring. To examine the effect of laser exposure on tissue scattering characteristics, the OCT backscattering intensities of non-ablated and ablated tissues were analyzed, and the effect on the skin microvasculature produced by laser ablation was quantitatively evaluated. Moreover, the integrated system and the proposed method were implemented for the treatment of skin and brain tumors on the mouse model. The obtained results indicate that the developed laser ablation system can effectively remove tumor tissues with controllable photodamage under OCT/OCTA guidance and that the system cost may be significantly reduced by using the CW laser diode.",

keywords = "Agriculture, Environment, Remote sensing, Robot arm, Robust control",

author = "Chen, {Wen Ju} and Chang, {Feng Yu} and Tsai, {Meng Tsan}",

note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; 6th Biomedical Imaging and Sensing Conference ; Conference date: 20-04-2020 Through 24-04-2020",

year = "2020",

doi = "10.1117/12.2573215",

language = "英语",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "SPIE",

editor = "Toyohiko Yatagai and Yoshihisa Aizu and Osamu Matoba and Yasuhiro Awatsuji and Yuan Luo",

booktitle = "Biomedical Imaging and Sensing Conference 2020",

address = "美国",

}

Chen, WJ, Chang, FY & Tsai, MT 2020, Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring. 於 T Yatagai, Y Aizu, O Matoba, Y Awatsuji & Y Luo (編輯), Biomedical Imaging and Sensing Conference 2020., 1152106, Proceedings of SPIE - The International Society for Optical Engineering, 卷 11521, SPIE, 6th Biomedical Imaging and Sensing Conference, Yokohama, 日本, 20/04/20. https://doi.org/10.1117/12.2573215

Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring. / Chen, Wen Ju; Chang, Feng Yu; Tsai, Meng Tsan.
Biomedical Imaging and Sensing Conference 2020. 編輯 / Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji; Yuan Luo. SPIE, 2020. 1152106 (Proceedings of SPIE - The International Society for Optical Engineering; 卷 11521).

研究成果: 圖書/報告稿件的類型 › 會議稿件 › 同行評審

TY - GEN

T1 - Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring

AU - Chen, Wen Ju

AU - Chang, Feng Yu

AU - Tsai, Meng Tsan

N1 - Publisher Copyright: © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

PY - 2020

Y1 - 2020

N2 - In this study, an integrated theranostic system combining a CW laser diode with optical coherence tomography (OCT)/angiography (OCTA) was utilized for tumor identification and treatment monitoring. To examine the effect of laser exposure on tissue scattering characteristics, the OCT backscattering intensities of non-ablated and ablated tissues were analyzed, and the effect on the skin microvasculature produced by laser ablation was quantitatively evaluated. Moreover, the integrated system and the proposed method were implemented for the treatment of skin and brain tumors on the mouse model. The obtained results indicate that the developed laser ablation system can effectively remove tumor tissues with controllable photodamage under OCT/OCTA guidance and that the system cost may be significantly reduced by using the CW laser diode.

AB - In this study, an integrated theranostic system combining a CW laser diode with optical coherence tomography (OCT)/angiography (OCTA) was utilized for tumor identification and treatment monitoring. To examine the effect of laser exposure on tissue scattering characteristics, the OCT backscattering intensities of non-ablated and ablated tissues were analyzed, and the effect on the skin microvasculature produced by laser ablation was quantitatively evaluated. Moreover, the integrated system and the proposed method were implemented for the treatment of skin and brain tumors on the mouse model. The obtained results indicate that the developed laser ablation system can effectively remove tumor tissues with controllable photodamage under OCT/OCTA guidance and that the system cost may be significantly reduced by using the CW laser diode.

KW - Agriculture

KW - Environment

KW - Remote sensing

KW - Robot arm

KW - Robust control

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M3 - 会议稿件

AN - SCOPUS:85087940303

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Biomedical Imaging and Sensing Conference 2020

A2 - Yatagai, Toyohiko

A2 - Aizu, Yoshihisa

A2 - Matoba, Osamu

A2 - Awatsuji, Yasuhiro

A2 - Luo, Yuan

PB - SPIE

T2 - 6th Biomedical Imaging and Sensing Conference

Y2 - 20 April 2020 through 24 April 2020

ER -

Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring

摘要

出版系列

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