Ovatodiolide inhibits the maturation of allergen-induced bone marrow-derived dendritic cells and induction of Th2 cell differentiation

Yerra Koteswara Rao, Yu Ching Chen, Shih Hua Fang, Chih Ho Lai, Madamanchi Geethangili, Chen Chen Lee*, Yew Min Tzeng

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

15 引文 斯高帕斯(Scopus)

摘要

Ovatodiolide was a unique macrocyclic diterpenoid isolated from the traditional Chinese medicinal herb Anisomeles indica. The present study attempted to examine the ovatodiolide effects on dendritic cell (DC) maturation and immuno-stimulatory activities. The effects of ovatodiolide on DC surface molecule expression, cytokine production, and capacity to induce T-cell differentiation were examined in ovalbumin (OVA)/thymic stromal lymphopoietin (TSLP)-stimulated DCs. Ovatodiolide attenuated the expression of DC surface molecules CD80, CD86, histocompatibility complex (MHC) class II, and Th2 subset of CD4+ T cells co-stimulatory molecule-OX40 ligand production. Additionally, ovatodiolide suppressed the CD4+ T cells proliferation, and production of inflammatory cytokines interleukin (IL)-4, IL-5, and tumor necrosis factor (TNF)-α. This study may be useful to develop ovatodiolide as a therapeutic adjuvant.

原文英語
頁(從 - 到)617-624
頁數8
期刊International Immunopharmacology
17
發行號3
DOIs
出版狀態已出版 - 2013
對外發佈

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