Pentatrichomonas hominis: Purine salvage pathway

Petrus Tang*, Hsin Sheng Lo

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

1. 1. Pentatrichomonas hominis was found incapable of de novo synthesis of purines. 2. 2. Pentatrichomonas hominis can salvage adenine, guanine, hypoxanthine, adenosine, guanosine and inosine, but not xanthine for the synthesis of nucleotides. 3. 3. HPLC tracing of radiolabelled purines or purine nucleosides revealed that adenine, adenosine and hypoxanthine are incorporatd into adenine nucleotides and IMP through a similar channel while guanine and guanosine are salvaged into guanine nucleotides via another route. There appears to be no direct interconversion between adenine and guanine nucleotides. Interconversion between AMP and IMP was observed. 4. 4. Assays of purine salvage enzymes revealed that P. hominis possesses adenosine kinase; adenosine, guanosine and inosine phosphotransferases; adenosine, guanosine and inosine phosphorylases and AMP deaminase.

原文英語
頁(從 - 到)419-425
頁數7
期刊Comparative Biochemistry and Physiology -- Part B: Biochemistry and
90
發行號2
DOIs
出版狀態已出版 - 1988
對外發佈

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