Phagocytes

The phagocyte lineage plays a crucial role in the immune system eliminating and destroying pathogens. In this chapter we examine neutrophils, eosinophils, basophils, mast cells, monocytes, macrophages, dendritic cells, and multinucleated cells, and provide a comprehensive view of the system's complexity. The chapter covers key aspects of the phagocyte system, beginning with an overview of its lineage. We discuss phagocyte identification and quantification methods and provide insights into the tools used to study their function. General phagocyte molecules are explored in the context of their diverse roles in the immune response. The process of phagocytosis, adhesion and chemotaxis mechanisms, are detailed to illustrate how phagocytes locate and engulf foreign particles. Additionally, we cover killing mechanisms such lytic enzymes and reactive radicals. We conclude by addressing disorders within the phagocyte system, including congenital disorders in neutrophils and genetic perspectives on monocyte/macrophage-related disorders.