@inproceedings{f4932dcdce914b12955a4884142be23a,
title = "Photosensitizer targeting: Mitochondria-targeted photosensitizer enhances photodynamic effect and apoptosis",
abstract = "Using multi-photon laser scanning imaging microscopy the effects of subcellular localized PDT with the photosensitizer BPD-MA was studied in different cellular compartments including the mitochondria, the cytosol and the nucleus. Specifically, mitochondrial reactive oxygen species (mROS) and mitochondrial free calcium (mCa2+) were measured simultaneously during PDT with BPD-MA induced mitochondrial dysfunction. Intriguingly, PDT with BPD-MA-induced mROS formation and mCa2+ elevation as well as apoptotic death were found only when the mitochondrial compartment was illuminated. These data suggest that PDT with a mitochondria targeted photosensitizer can extensively enhance the efficacy of PDT via mROS and mCa2+-mediated apoptotic mechanisms.",
keywords = "Apoptosis, BPD-MA, Imaging microscopy, MCa, MROS, Mitochondria, Photodynamic therapy",
author = "Jou, \{Mei Jie\}",
year = "2004",
language = "英语",
isbn = "0780386760",
series = "Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004",
pages = "91--92",
booktitle = "Second Asian and Pacific Rim Symposium on Biophotonics - Proceedings, APBP 2004",
note = "Second Asian and Pacific Rim Symposium on Biophotonics, APBP 2004 ; Conference date: 15-12-2004 Through 17-12-2004",
}