phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development

Haiwei Pi; Shao Kuei Huang; Chiou Yang Tang; Y. Henry Sun; Cheng Ting Chien

doi:10.1073/pnas.0306010101

phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development

Haiwei Pi, Shao Kuei Huang, Chiou Yang Tang, Y. Henry Sun, Cheng Ting Chien^*

^*此作品的通信作者

研究成果: 期刊稿件 › 文章 › 同行評審

32 引文斯高帕斯（Scopus）

摘要

Proneural basic helix-loop-helix (bHLH) proteins initiate neurogenesis in both vertebrates and invertebrates. The Drosophila Achaete (Ac) and Scute (Sc) proteins are among the first identified members of the large bHLH proneural protein family. phyllopod (phyl), encoding an ubiquitin ligase adaptor, is required for ac- and sc-dependent external sensory (ES) organ development. Expression of phyl is directly activated by Ac and Sc. Forced expression of phyl rescues ES organ formation in ac and sc double mutants. phyl and senseless, encoding a Zn-finger transcriptional factor, depend on each other in ES organ development. Our results provide the first example that bHLH proneural proteins promote neurogenesis through regulation of protein degradation.

原文	英語
頁（從 - 到）	8378-8383
頁數	6
期刊	Proceedings of the National Academy of Sciences of the United States of America
卷	101
發行號	22
DOIs	https://doi.org/10.1073/pnas.0306010101
出版狀態	已出版 - 01 06 2004
對外發佈	是

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abstract = "Proneural basic helix-loop-helix (bHLH) proteins initiate neurogenesis in both vertebrates and invertebrates. The Drosophila Achaete (Ac) and Scute (Sc) proteins are among the first identified members of the large bHLH proneural protein family. phyllopod (phyl), encoding an ubiquitin ligase adaptor, is required for ac- and sc-dependent external sensory (ES) organ development. Expression of phyl is directly activated by Ac and Sc. Forced expression of phyl rescues ES organ formation in ac and sc double mutants. phyl and senseless, encoding a Zn-finger transcriptional factor, depend on each other in ES organ development. Our results provide the first example that bHLH proneural proteins promote neurogenesis through regulation of protein degradation.",

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AU - Pi, Haiwei

AU - Huang, Shao Kuei

AU - Tang, Chiou Yang

AU - Sun, Y. Henry

AU - Chien, Cheng Ting

PY - 2004/6/1

Y1 - 2004/6/1

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KW - E3 ligase

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KW - Senseless

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DO - 10.1073/pnas.0306010101

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development

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