TY - CHAP
T1 - Pore size and functional properties of defined MAC and poly C9 complexes
T2 - Reconstitution into model lipid membranes
AU - Young, John Ding E.
AU - Cohn, Zanvil A.
AU - Podack, Eckhard R.
N1 - Publisher Copyright:
© 1988 by CRC Press, Inc.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The membrane attack complex (MAC) of complement is formed by the assembly of the five terminal components of complement in the target cell membrane which results in membrane damage and cytolysis. Ultrastructural studies have shown that membranes damaged by the MAC show tubular membrane lesions of approximately 100 A in internal diameter.1-4 These observations are consistent with the doughnut channel model for complement-mediated killing proposed earlier by Mayer. 5 The assembly of these membraneattack components involves an initial insertion of C5b-7 into membrane6, followed by the subsequent binding of C8 and C9 to form the tubular lesion7,8. C9 appears to be responsible largely for the formation of the tubular structure associated with the MAC.4,9,10 Polymerization of C9 into circular lesions occurs after prolonged incubation of the monomer at temperature exceeding 37°C.11,12.
AB - The membrane attack complex (MAC) of complement is formed by the assembly of the five terminal components of complement in the target cell membrane which results in membrane damage and cytolysis. Ultrastructural studies have shown that membranes damaged by the MAC show tubular membrane lesions of approximately 100 A in internal diameter.1-4 These observations are consistent with the doughnut channel model for complement-mediated killing proposed earlier by Mayer. 5 The assembly of these membraneattack components involves an initial insertion of C5b-7 into membrane6, followed by the subsequent binding of C8 and C9 to form the tubular lesion7,8. C9 appears to be responsible largely for the formation of the tubular structure associated with the MAC.4,9,10 Polymerization of C9 into circular lesions occurs after prolonged incubation of the monomer at temperature exceeding 37°C.11,12.
UR - http://www.scopus.com/inward/record.url?scp=85025500446&partnerID=8YFLogxK
U2 - 10.1201/9781351071307
DO - 10.1201/9781351071307
M3 - 章节
AN - SCOPUS:85025500446
SN - 9781315892207
VL - 1
SP - 221
EP - 227
BT - Cytolytic Lymphocytes and Complement Effectors of the Immune System
PB - CRC Press
ER -