Potential modulation on P-glycoprotein and CYP3A by soymilk and miso: In vivo and ex-vivo studies

C. P. Yu, Y. W. Hsieh, S. P. Lin, Y. C. Chi, P. Hariharan, P. D.L. Chao*, Y. C. Hou

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

13 引文 斯高帕斯(Scopus)

摘要

P-glycoprotein (P-gp) and CYP3A4 both play very important roles in drug bioavailability, resistance and interactions. Our in vitro studies indicated that P-gp function was activated by many isoflavones. This study investigated the in vivo effects of soymilk and miso, isoflavone-rich soy foods, on P-gp and CYP3A by tracing the pharmacokinetics of cyclosporine (CSP), a probe drug of P-gp. Rats were orally administered CSP with and without soymilk or miso. A specific monoclonal fluorescence polarisation immunoassay was used to determine the blood concentration of CSP. The results showed that soymilk and miso significantly decreased the Cmax of CSP by 64.5% and 78.3%, and reduced the AUC0-540 by 64.9% and 78.3%, respectively. Mechanism studies revealed that the activities of P-gp and CYP3A4 were induced by soymilk and miso. In conclusion, ingestion of soymilk and miso significantly activated the functions of P-gp and CYP3A.

原文英語
頁(從 - 到)25-30
頁數6
期刊Food Chemistry
149
DOIs
出版狀態已出版 - 2014
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