Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: Intravenous bolus administration

Ming Hwang Shyr, Chen Hsien Yang, Terry B.J. Kuo, Wynn H.T. Pan, Peter P.C. Tan, Samuel H.H. Chan*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

22 引文 斯高帕斯(Scopus)

摘要

Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that the minimal effective antinociceptive dose of propofol in adult, male Sprague-Dawley rats, given in an intravenous bolus manner, was 10 mg/kg. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant transient suppression of the EEG activity, primarily in the θ{symbol} and σ bands, alongside minor hypotensive and negative inotropic and chronotropic actions, but with maintained vasomotor tone. These alterations followed a time course that paralleled the plasma concentration of propofol in the arterial blood, as detected by high-performance liquid chromatography.

原文英語
頁(從 - 到)161-164
頁數4
期刊Neuroscience Letters
153
發行號2
DOIs
出版狀態已出版 - 30 04 1993
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