摘要
Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that the minimal effective antinociceptive dose of propofol in adult, male Sprague-Dawley rats, given in an intravenous bolus manner, was 10 mg/kg. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant transient suppression of the EEG activity, primarily in the θ{symbol} and σ bands, alongside minor hypotensive and negative inotropic and chronotropic actions, but with maintained vasomotor tone. These alterations followed a time course that paralleled the plasma concentration of propofol in the arterial blood, as detected by high-performance liquid chromatography.
原文 | 英語 |
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頁(從 - 到) | 161-164 |
頁數 | 4 |
期刊 | Neuroscience Letters |
卷 | 153 |
發行號 | 2 |
DOIs | |
出版狀態 | 已出版 - 30 04 1993 |
對外發佈 | 是 |