Preventive aspects of early resveratrol supplementation in cardiovascular and kidney disease of developmental origins

Chien Ning Hsu, Chih Yao Hou, You Lin Tain*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

28 引文 斯高帕斯(Scopus)

摘要

The increase in the incidence of cardiovascular diseases (CVDs) and kidney disease has stimulated research for strategies that could prevent, rather than just treat, both interconnected disorders. Resveratrol, a polyphenolic compound with pleiotropic biofunctions, has shown health benefits. Emerging epidemiological data supports that early life environmental insults are regarded as increased risks of developing CVDs and kidney disease in adulthood. Conversely, both disorders could be reversed or postponed by shifting interventions from adulthood to earlier stage by so-called reprogramming. The purpose of this review is first to highlight current epidemiological studies linking cardiovascular and renal programming to resulting CVD and kidney disease of developmental origins. This will be followed by a summary of how resveratrol could exert a positive influence on CVDs and kidney disease. This review also presents an overview of the evidence documenting resveratrol as a reprogramming agent to protect against CVD and kidney disease of developmental origins from animal studies and to outline the advances in understanding the underlying molecular mechanisms. Overall, this review reveals the need for future research to further clarify the reprogramming effects of resveratrol before clinical translation.

原文英語
文章編號4210
期刊International Journal of Molecular Sciences
22
發行號8
DOIs
出版狀態已出版 - 02 04 2021

文獻附註

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© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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