Prognostic roles of SCC antigen, CRP and Cyfra 21-1 in oral cavity squamous cell carcinoma

Dante de Paz; Chi Kuang Young; Huei Tzu Chien; Chung Kang Tsao; Cheong Chon Fok; Kang Hsing Fan; Chun Ta Liao; Hung Ming Wang; Chung Jan Kang; Joseph Tung Chieh Chang; Shiang Fu Huang

doi:10.21873/anticanres.13313

Prognostic roles of SCC antigen, CRP and Cyfra 21-1 in oral cavity squamous cell carcinoma

Dante de Paz, Chi Kuang Young, Huei Tzu Chien, Chung Kang Tsao, Cheong Chon Fok, Kang Hsing Fan, Chun Ta Liao, Hung Ming Wang, Chung Jan Kang, Joseph Tung Chieh Chang, Shiang Fu Huang^*

^*此作品的通信作者

研究成果: 期刊稿件 › 文章 › 同行評審

23 引文斯高帕斯（Scopus）

摘要

Background/Aim: Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients. Patients and Methods: Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016. Results: The elevation of CRP levels (≥5.0 mg/l) and SCC-Ag levels (≥2.0 ng/ml) were significantly related with tumor invasion parameters and metastatic factors. In contrast, the elevation of CYFRA 21-1 levels (≥3.3 ng/ml) was related with extranodal extension alone.

原文	英語
頁（從 - 到）	2025-2033
頁數	9
期刊	Anticancer Research
卷	39
發行號	4
DOIs	https://doi.org/10.21873/anticanres.13313
出版狀態	已出版 - 04 2019

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© 2019 International Institute of Anticancer Research. All rights reserved.

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@article{9764634c6fa14646a8b8080f6e6ed00b,

title = "Prognostic roles of SCC antigen, CRP and Cyfra 21-1 in oral cavity squamous cell carcinoma",

abstract = "Background/Aim: Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients. Patients and Methods: Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016. Results: The elevation of CRP levels (≥5.0 mg/l) and SCC-Ag levels (≥2.0 ng/ml) were significantly related with tumor invasion parameters and metastatic factors. In contrast, the elevation of CYFRA 21-1 levels (≥3.3 ng/ml) was related with extranodal extension alone.",

keywords = "C-reactive protein, CYFRA 21-1, Oral cavity, Prognosis, SCC antigen, Squamous cell carcinoma",

author = "{de Paz}, Dante and Young, {Chi Kuang} and Chien, {Huei Tzu} and Tsao, {Chung Kang} and Fok, {Cheong Chon} and Fan, {Kang Hsing} and Liao, {Chun Ta} and Wang, {Hung Ming} and Kang, {Chung Jan} and Chang, {Joseph Tung Chieh} and Huang, {Shiang Fu}",

year = "2019",

month = apr,

doi = "10.21873/anticanres.13313",

language = "英语",

volume = "39",

pages = "2025--2033",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "4",

}

TY - JOUR

T1 - Prognostic roles of SCC antigen, CRP and Cyfra 21-1 in oral cavity squamous cell carcinoma

AU - de Paz, Dante

AU - Young, Chi Kuang

AU - Chien, Huei Tzu

AU - Tsao, Chung Kang

AU - Fok, Cheong Chon

AU - Fan, Kang Hsing

AU - Liao, Chun Ta

AU - Wang, Hung Ming

AU - Kang, Chung Jan

AU - Chang, Joseph Tung Chieh

AU - Huang, Shiang Fu

PY - 2019/4

Y1 - 2019/4

N2 - Background/Aim: Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients. Patients and Methods: Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016. Results: The elevation of CRP levels (≥5.0 mg/l) and SCC-Ag levels (≥2.0 ng/ml) were significantly related with tumor invasion parameters and metastatic factors. In contrast, the elevation of CYFRA 21-1 levels (≥3.3 ng/ml) was related with extranodal extension alone.

AB - Background/Aim: Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients. Patients and Methods: Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016. Results: The elevation of CRP levels (≥5.0 mg/l) and SCC-Ag levels (≥2.0 ng/ml) were significantly related with tumor invasion parameters and metastatic factors. In contrast, the elevation of CYFRA 21-1 levels (≥3.3 ng/ml) was related with extranodal extension alone.

KW - C-reactive protein

KW - CYFRA 21-1

KW - Oral cavity

KW - Prognosis

KW - SCC antigen

KW - Squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=85064520751&partnerID=8YFLogxK

U2 - 10.21873/anticanres.13313

DO - 10.21873/anticanres.13313

M3 - 文章

C2 - 30952746

AN - SCOPUS:85064520751

SN - 0250-7005

VL - 39

SP - 2025

EP - 2033

JO - Anticancer Research

JF - Anticancer Research

IS - 4

ER -

Prognostic roles of SCC antigen, CRP and Cyfra 21-1 in oral cavity squamous cell carcinoma

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