Prognostic roles of SCC antigen, CRP and Cyfra 21-1 in oral cavity squamous cell carcinoma

Dante de Paz; Chi Kuang Young; Huei Tzu Chien; Chung Kang Tsao; Cheong Chon Fok; Kang Hsing Fan; Chun Ta Liao; Hung Ming Wang; Chung Jan Kang; Joseph Tung Chieh Chang; Shiang Fu Huang

doi:10.21873/anticanres.13313

Prognostic roles of SCC antigen, CRP and Cyfra 21-1 in oral cavity squamous cell carcinoma

Dante de Paz
, Chi Kuang Young
, Huei Tzu Chien
, Chung Kang Tsao
, Cheong Chon Fok
, Kang Hsing Fan
, Chun Ta Liao
, Hung Ming Wang
, Chung Jan Kang
, Joseph Tung Chieh Chang
, Shiang Fu Huang^*

^*此作品的通信作者

研究成果: 期刊稿件 › 文章 › 同行評審

25 引文斯高帕斯（Scopus）

摘要

Background/Aim: Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients. Patients and Methods: Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016. Results: The elevation of CRP levels (≥5.0 mg/l) and SCC-Ag levels (≥2.0 ng/ml) were significantly related with tumor invasion parameters and metastatic factors. In contrast, the elevation of CYFRA 21-1 levels (≥3.3 ng/ml) was related with extranodal extension alone.

原文	英語
頁（從 - 到）	2025-2033
頁數	9
期刊	Anticancer Research
卷	39
發行號	4
DOIs	https://doi.org/10.21873/anticanres.13313
出版狀態	已出版 - 04 2019

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© 2019 International Institute of Anticancer Research. All rights reserved.

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@article{9764634c6fa14646a8b8080f6e6ed00b,

title = "Prognostic roles of SCC antigen, CRP and Cyfra 21-1 in oral cavity squamous cell carcinoma",

abstract = "Background/Aim: Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients. Patients and Methods: Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016. Results: The elevation of CRP levels (≥5.0 mg/l) and SCC-Ag levels (≥2.0 ng/ml) were significantly related with tumor invasion parameters and metastatic factors. In contrast, the elevation of CYFRA 21-1 levels (≥3.3 ng/ml) was related with extranodal extension alone.",

keywords = "C-reactive protein, CYFRA 21-1, Oral cavity, Prognosis, SCC antigen, Squamous cell carcinoma",

author = "\{de Paz\}, Dante and Young, \{Chi Kuang\} and Chien, \{Huei Tzu\} and Tsao, \{Chung Kang\} and Fok, \{Cheong Chon\} and Fan, \{Kang Hsing\} and Liao, \{Chun Ta\} and Wang, \{Hung Ming\} and Kang, \{Chung Jan\} and Chang, \{Joseph Tung Chieh\} and Huang, \{Shiang Fu\}",

year = "2019",

month = apr,

doi = "10.21873/anticanres.13313",

language = "英语",

volume = "39",

pages = "2025--2033",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "4",

}

TY - JOUR

T1 - Prognostic roles of SCC antigen, CRP and Cyfra 21-1 in oral cavity squamous cell carcinoma

AU - de Paz, Dante

AU - Young, Chi Kuang

AU - Chien, Huei Tzu

AU - Tsao, Chung Kang

AU - Fok, Cheong Chon

AU - Fan, Kang Hsing

AU - Liao, Chun Ta

AU - Wang, Hung Ming

AU - Kang, Chung Jan

AU - Chang, Joseph Tung Chieh

AU - Huang, Shiang Fu

PY - 2019/4

Y1 - 2019/4

N2 - Background/Aim: Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients. Patients and Methods: Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016. Results: The elevation of CRP levels (≥5.0 mg/l) and SCC-Ag levels (≥2.0 ng/ml) were significantly related with tumor invasion parameters and metastatic factors. In contrast, the elevation of CYFRA 21-1 levels (≥3.3 ng/ml) was related with extranodal extension alone.

AB - Background/Aim: Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients. Patients and Methods: Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016. Results: The elevation of CRP levels (≥5.0 mg/l) and SCC-Ag levels (≥2.0 ng/ml) were significantly related with tumor invasion parameters and metastatic factors. In contrast, the elevation of CYFRA 21-1 levels (≥3.3 ng/ml) was related with extranodal extension alone.

KW - C-reactive protein

KW - CYFRA 21-1

KW - Oral cavity

KW - Prognosis

KW - SCC antigen

KW - Squamous cell carcinoma

UR - https://www.scopus.com/pages/publications/85064520751

U2 - 10.21873/anticanres.13313

DO - 10.21873/anticanres.13313

M3 - 文章

C2 - 30952746

AN - SCOPUS:85064520751

SN - 0250-7005

VL - 39

SP - 2025

EP - 2033

JO - Anticancer Research

JF - Anticancer Research

IS - 4

ER -

Prognostic roles of SCC antigen, CRP and Cyfra 21-1 in oral cavity squamous cell carcinoma

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