Prognostic value of global left ventricular strain for conservatively treated patients with symptomatic aortic stenosis

Hsin Fu Lee, Lung An Hsu, Yi Hsin Chan, Chun Li Wang*, Chi Jen Chang, Chi Tai Kuo

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

30 引文 斯高帕斯(Scopus)

摘要

Aims: Impaired left ventricular (LV) strain is associated with an increased risk of cardiac events in asymptomatic severe aortic stenosis (AS). We aimed to evaluate the prognostic value of global LV strain in conservatively treated patients with symptomatic AS. Methods and results: This cohort study retrospectively reviewed symptomatic AS patients who were treated conservatively or surgically between July 2007 and April 2010. We measured their global longitudinal strain (GLS) and global circumferential strain (GCS). Clinical events were defined as readmission for heart failure or all-cause death for 2 years. GLS and GCS could predict a worse outcome in the conservatively treated group at cut-offs of =-16.5% (77% sensitivity and 67% specificity) and =-22.2% (92% sensitivity and 83% specificity), respectively. By univariate Cox regression analysis, age, logistic EuroSCORE, aortic valve area, GLS, and GCS were significant predictors. When adjusted for age, logistic EuroSCORE, and aortic valve area, impaired GLS and GCS were independently associated with a higher risk of clinical events. Conclusion: In conservatively treated patients with symptomatic AS, impaired GLS and GCS were associated with an increased risk of cardiac events during a 2-year follow-up. Global LV strain may help to define a higher risk subset; therefore, a larger and prospective observation study would be necessary.

原文英語
頁(從 - 到)301-306
頁數6
期刊Journal of Cardiology
62
發行號5
DOIs
出版狀態已出版 - 11 2013

指紋

深入研究「Prognostic value of global left ventricular strain for conservatively treated patients with symptomatic aortic stenosis」主題。共同形成了獨特的指紋。

引用此