Prompt bone marrow-derived mesenchymal stem cell therapy enables early porcine heart function recovery from acute myocardial infarction

Chang Qing Fan, Steve Leu, Jiunn Jye Sheu, Yen Yi Zhen, Tzu Hsien Tsai, Yung Lung Chen, Sheng Ying Chung, Han Tan Chai, Cheuk Kwan Sun, Jenq Lin Yang, Hsueh Wen Chang, Sheung Fat Ko, Hon Kan Yip*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

Impact of early bone marrow-derived mesenchymal stem cell (BMDMSC) implantation on left ventricular (LV) function after AMI was studied. Twelve mini-pigs were equally divided into placebo (AMI through left coronary artery ligation) and cell-treated groups [BMDMSCs (3.0 × 107) implanted into infarct area (IA)] with myocardium harvested by post-AMI day 90. Six healthy animals served as controls. On post-AMI day 90, magnetic resonance imaging showed a lower LV ejection fraction but higher LV dimensions in the placebo group (P < 0.003) that also had increased IAs but reduced wall thickness (P < 0.005). Pro-apoptotic gene expressions (Bax, caspase-3) and apoptotic nucleus number in IAs and peri-IAs were highest in the placebo group (P < 0.001). Inflammatory biomarker expressions (MMP-9, oxidized protein, CD40+ cells) were highest, whereas those of angiogenesis (VEGF, CD31+ cells, SDF-1α, CXCR4) and myocardium-preservation (connexin43, troponin-I, cytochrome- C) were lowest in the placebo group (P < 0.01). BMDMSC implantation preserved LV function and alleviated remodeling at post-AMI day 90.

原文英語
頁(從 - 到)362-371
頁數10
期刊International Heart Journal
55
發行號4
DOIs
出版狀態已出版 - 2014

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