Properties of vitamin E-deficient erythrocytes following peroxidant injury

Bertram Lubin, Danny Chiu*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

35 引文 斯高帕斯(Scopus)

摘要

Several membrane properties of vitamin E-deficient and normal erythrocytes were studied after incubation of these cells with hydrogen peroxide. Measurements of mean corpuscular volume, cation permeability, membrane Na+, K+ ATPase activity, red cell filterability through 5 ju millipore filters, and membrane protein pattern on sodium dodecyle sulfate-gel electrophoresis revealed marked alterations before lysis. Vitamin E sufficient cells were unaffected by a similar incubation with hydrogen peroxide. We speculate that the changes in membrane function, which follow peroxidant injury, contribute to the shortened red cell survival in the vitamin E deficient state.

原文英語
頁(從 - 到)928-932
頁數5
期刊Pediatric Research
16
發行號11
DOIs
出版狀態已出版 - 11 1982
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