Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer

Yao Kuang Wu; Kuei Tien Chen; Yung Bin Kuo; Ya Shu Huang; Err Cheng Chan

doi:10.1016/j.canlet.2008.08.023

Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer

Yao Kuang Wu
, Kuei Tien Chen
, Yung Bin Kuo
, Ya Shu Huang
, Err Cheng Chan^*

^*此作品的通信作者

醫學生物技術暨檢驗學系(含學碩博士班)

Buddhist Tzu-Chi General Hospital Taiwan
Chang Gung University
National Yang Ming Chiao Tung University

研究成果: 期刊稿件 › 文章 › 同行評審

32 引文斯高帕斯（Scopus）

摘要

In the present study, pleural effusions are the first time to be used as the specimens for detection of survivin expression in lung cancer patients. We demonstrated that by quantifying survivin expression with enzyme-linked immunosorbent assay (ELISA) in the 80 effusion samples exhibited a diagnostic power of 85% and 75% in sensitivity and specificity, respectively. A multivariate analysis with the Cox regression model revealed that both high survivin expression and cancer cells of stage IV were the indicators for poor prognosis of lung cancer. In conclusion, quantitative assay of survivin in pleural effusion could be useful both in diagnosis and prognosis for lung cancer.

原文	英語
頁（從 - 到）	331-335
頁數	5
期刊	Cancer Letters
卷	273
發行號	2
DOIs	https://doi.org/10.1016/j.canlet.2008.08.023
出版狀態	已出版 - 18 01 2009

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@article{e8d45f1a8e4a421a9ca5226a839b0576,

title = "Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer",

abstract = "In the present study, pleural effusions are the first time to be used as the specimens for detection of survivin expression in lung cancer patients. We demonstrated that by quantifying survivin expression with enzyme-linked immunosorbent assay (ELISA) in the 80 effusion samples exhibited a diagnostic power of 85\% and 75\% in sensitivity and specificity, respectively. A multivariate analysis with the Cox regression model revealed that both high survivin expression and cancer cells of stage IV were the indicators for poor prognosis of lung cancer. In conclusion, quantitative assay of survivin in pleural effusion could be useful both in diagnosis and prognosis for lung cancer.",

keywords = "Lung cancer, Pleural effusion, Prognosis, Survival rate, Survivin expression",

author = "Wu, \{Yao Kuang\} and Chen, \{Kuei Tien\} and Kuo, \{Yung Bin\} and Huang, \{Ya Shu\} and Chan, \{Err Cheng\}",

year = "2009",

month = jan,

day = "18",

doi = "10.1016/j.canlet.2008.08.023",

language = "英语",

volume = "273",

pages = "331--335",

journal = "Cancer Letters",

issn = "0304-3835",

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number = "2",

}

TY - JOUR

T1 - Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer

AU - Wu, Yao Kuang

AU - Chen, Kuei Tien

AU - Kuo, Yung Bin

AU - Huang, Ya Shu

AU - Chan, Err Cheng

PY - 2009/1/18

Y1 - 2009/1/18

N2 - In the present study, pleural effusions are the first time to be used as the specimens for detection of survivin expression in lung cancer patients. We demonstrated that by quantifying survivin expression with enzyme-linked immunosorbent assay (ELISA) in the 80 effusion samples exhibited a diagnostic power of 85% and 75% in sensitivity and specificity, respectively. A multivariate analysis with the Cox regression model revealed that both high survivin expression and cancer cells of stage IV were the indicators for poor prognosis of lung cancer. In conclusion, quantitative assay of survivin in pleural effusion could be useful both in diagnosis and prognosis for lung cancer.

AB - In the present study, pleural effusions are the first time to be used as the specimens for detection of survivin expression in lung cancer patients. We demonstrated that by quantifying survivin expression with enzyme-linked immunosorbent assay (ELISA) in the 80 effusion samples exhibited a diagnostic power of 85% and 75% in sensitivity and specificity, respectively. A multivariate analysis with the Cox regression model revealed that both high survivin expression and cancer cells of stage IV were the indicators for poor prognosis of lung cancer. In conclusion, quantitative assay of survivin in pleural effusion could be useful both in diagnosis and prognosis for lung cancer.

KW - Lung cancer

KW - Pleural effusion

KW - Prognosis

KW - Survival rate

KW - Survivin expression

UR - https://www.scopus.com/pages/publications/57449085352

U2 - 10.1016/j.canlet.2008.08.023

DO - 10.1016/j.canlet.2008.08.023

M3 - 文章

C2 - 18824294

AN - SCOPUS:57449085352

SN - 0304-3835

VL - 273

SP - 331

EP - 335

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer

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