Randainins A-D, Based on Unique Diterpenoid Architectures, from Callicarpa randaiensis

Ho Hsi Cheng, Yuan Bin Cheng, Tsong Long Hwang, Yao Haur Kuo, Chung Hsiung Chen, Ya Ching Shen*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

16 引文 斯高帕斯(Scopus)

摘要

Four new compounds, randainins A-D (1-4), were isolated from the leaves and twigs of Callicarpa randaiensis, which is an endemic species in Taiwan. Compounds 1 and 2 are diterpenoids with an unusual trans-7/5 ring system, whereas compounds 3 and 4 are diterpenoids possessing a trans-5/7 ring scaffold. The structures of the new compounds were established based on NMR and MS data analyses. Anti-inflammatory activities and cytotoxicity were tested and evaluated for these compounds. Compound 4 exhibited moderate inhibition of superoxide-anion generation with an IC50 value of 21.5 ± 2.5 μM. (Figure Presented).

原文英語
頁(從 - 到)1823-1828
頁數6
期刊Journal of Natural Products
78
發行號8
DOIs
出版狀態已出版 - 28 08 2015

文獻附註

Publisher Copyright:
© 2015 American Chemical Society and American Society of Pharmacognosy.

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