Regulation Mechanisms of Viral IRES-Driven Translation

Kuo Ming Lee, Chi Jene Chen, Shin Ru Shih*

*此作品的通信作者

研究成果: 期刊稿件文獻綜述同行評審

114 引文 斯高帕斯(Scopus)

摘要

Internal ribosome entry sites (IRESs) can be found in the mRNA of many viruses as well as in cellular genes involved in the stress response, cell cycle, and apoptosis. IRES-mediated translation can occur when dominant cap-dependent translation is inhibited, and viruses can take advantage of this to subvert host translation machinery. In this review, we focus on the four major types of IRES identified in RNA viruses, and outline their distinct structural properties and requirements of translational factors. We further discuss auxiliary host factors known as IRES trans-acting factors (ITAFs), which are involved in the modulation of optimal IRES activity. Currently known strategies employed by viruses to harness ITAFs and regulate IRES activity are also highlighted.

原文英語
頁(從 - 到)546-561
頁數16
期刊Trends in Microbiology
25
發行號7
DOIs
出版狀態已出版 - 07 2017

文獻附註

Publisher Copyright:
© 2017 Elsevier Ltd

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