Risk of new-onset diabetes in end-stage renal disease patients undergoing dialysis: Analysis from registry data of Taiwan

I. Kuan Wang, Cheng Li Lin, Hung Chih Chen, Shih Yi Lin, Chiz Tzung Chang, Tzung Hai Yen, Fung Chang Sung*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

28 引文 斯高帕斯(Scopus)

摘要

Background This study compared the risk of developing new-onset diabetes between hemodialysis (HD) and peritoneal dialysis (PD) patients. We further investigated the effectiveness of icodextrin in reducing the risk of new-onset diabetes in PD patients. Methods From the Taiwan health insurance database, 36 879 incident HD patients and 6382 incident PD patients from 2000 to 2010 were identified as study cohorts. We further selected an additional HD cohort matched by propensity scores (PSs) of PD patients. Incidence rates and hazard ratios (HRs) of new-onset diabetes were assessed among cohorts and between icodextrin users and nonusers by the end of 2011. Results For the unmatched cohorts, the incidence of new-onset diabetes was higher in PD patients than in HD patients (9.16 versus 8.18 per 1000 person-years), with an adjusted HR of 1.51 (95% CI 1.30-1.75) for PD patients. For the PS-matched cohorts, the corresponding incidence rates were 9.43 and 5.90 per 1000 person-years, respectively, with an adjusted HR of 1.61 (95% CI 1.32-1.97). Among PD patients, the incidence was lower in icodextrin users than in nonusers (6.22 versus 12.1 per 1000 person-years), with an adjusted HR of 0.66 (95% CI 0.50-0.88) for users. Conclusions Our study suggests that PD patients are at a higher risk of developing new-onset diabetes than HD patients. Icodextrin is recommended for PD patients to reduce the risk of new-onset diabetes.

原文英語
頁(從 - 到)670-675
頁數6
期刊Nephrology Dialysis Transplantation
33
發行號4
DOIs
出版狀態已出版 - 01 04 2018

文獻附註

Publisher Copyright:
© 2017 The Author. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

指紋

深入研究「Risk of new-onset diabetes in end-stage renal disease patients undergoing dialysis: Analysis from registry data of Taiwan」主題。共同形成了獨特的指紋。

引用此