Risk of peripheral arterial occlusive disease in patients with systemic lupus erythematosus a nationwide population-based cohort study

Ya Wen Chuang, Mei Ching Yu, Cheng Li Lin, Tung Min Yu, Kuo Hsiung Shu, Chia Hung Kao*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

26 引文 斯高帕斯(Scopus)

摘要

Systemic lupus erythematosus (SLE) is associated with atherosclerosis, but the relationship between SLE and peripheral arterial occlusive disease (PAOD) remains unclear. We sought to investigate this relationship by comparing cardiovascular complications in patients with and without SLE. Data on patients from 2000 to 2011 were collected from the National Health Insurance Research Database of Taiwan. The SLE cohort was frequency-matched according to age, sex, and history of diabetes mellitus (DM) with patients without SLE (control cohort). We evaluated the risk of cardiovascular complications, including hypertension, DM, stroke, chronic obstructive pulmonary disease, heart failure, coronary artery disease, and hyperlipidemia. The study included 10,144 patients with SLE and 10,144 control patients. The incidence of PAOD was 9.39-fold higher (95% confidence interval [CI]7.70-11.15) in the SLE cohort than in the non-SLE cohort. Moreover, SLE was an independent risk factor for PAOD. The adjusted risk of PAOD was highest in patients with SLE who were aged 34 years (hazard ratio47.6, 95% CI26.8-84.4). The risk of PAOD was highest during the first year of follow-up and decreased over time. Patients with SLE exhibit a higher incidence and an independently higher risk of PAOD compared with the general population. The PAOD risk is markedly elevated in patients with SLE who are young and in whom the disease is at an early stage.

原文英語
頁(從 - 到)e2121
期刊Medicine (United States)
94
發行號46
DOIs
出版狀態已出版 - 2015

文獻附註

Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc. All rights reserved.

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