ROX評分預測新型冠狀病毒病人使用高流量鼻導管之成功率

Background and Purpose: Regular exercise ameliorates cardiorespiratory fitness and is associated with immune regulation. Circuit exercise is a relevantly new concept involving multi-station training and targeting multiple major muscle groups. Although previous studies reported benefits of improved physical fitness with lesser fatigue experienced during exercise, most of the research involved resistance exercise or functional training. How aerobic exercise in a circuit pattern affects immunity was not explored. This study aimed to investigate the effects of a 6-week circuit aerobic exercise, as compared to cycling exercise, on exercise performance and neutrophil function. Methods: We recruited and randomised 16 inactive young men to the circuit exercise group (CAT, n = 8, cycling-rowing-elliptical training, each 10-minute bout) or cycling exercise group (CYC, n = 8, cycling, 3 sets of 10-minute bout) with moderate intensity (60% of heart rate reserve), 5 days/week for 6 weeks. Participants' body composition and cardiorespiratory fitness, were assessed before and after training, using cardiopulmonary exercise testing, respectively. Venous blood samples were collected for analysis of neutrophils, in which phagocytosis ability and respiratory burst upon an acute bout of severe exercise were examined using a flow cytometer. Results: At baseline, CAT and CYC did not show significant differences in mean age, body composition, and cardiorespiratory fitness (VO_(2peak) = 30.97 ± 2.93 and 27.86 ± 1.11, respectively). After training, both groups showed significant improvement in VO_(2peak) (within-group mean difference 4.23 ± 0.8, p < 0.001 and 7.91 ± 0.13, p < 0.001, for CAT and CYC, respectively). Significant training-induced increment of phagocytosis ability in neutrophils was observed in CYC (p < 0.05), but not CAT. Meanwhile, acute severe exercise suppressed the respiratory burst of neutrophils which was attenuated after 6 weeks of training in both groups. Conclusions: A 6-week circuit aerobic exercise improves cardiorespiratory fitness in inactive men along with improved immune response upon acute stress. Clinical Relevance: This study suggested circuit aerobic exercise as an alternative training for inactive individuals with a potential influence on innate immune response.