Saca chip enabled circulating tumor cell clusters phenotyping for cancer immunotherapy response monitoring

Chun Jieh Hsu; Yu Chia Kan; Chun Wei Lee; Jen Kuei Wu; Kang Yun Lee; Po Hao Feng; Wei Chiao Chang; Fan Gang Tseng

Saca chip enabled circulating tumor cell clusters phenotyping for cancer immunotherapy response monitoring

Chun Jieh Hsu, Yu Chia Kan, Chun Wei Lee, Jen Kuei Wu, Kang Yun Lee, Po Hao Feng, Wei Chiao Chang, Fan Gang Tseng^*

^*此作品的通信作者

研究成果: 圖書/報告稿件的類型 › 會議稿件 › 同行評審

摘要

In the present study, we indicated that the detection of specific subtypes of circulating tumor microemboli (CTM) in post-operative patients could help predict cancer recurrence. By using conventional strategies for detection of non-small-cell lung cancer (NSCLC) circulating tumor cells, is significantly limited due to inherently heterogeneous and dynamic expression of EpCAM, and degradation of cytokeratins during epithelial-tomesenchymal transition. These lead to non-negligible false negative detection of “uncapturable and invisible” single CTCs. To solve the problem, we investigated the clinical significance of CTM subtypes, including single CTCs, multi-CTCs cluster, and WBC-CTCs cluster on SACA chip for studying cancer metastasis and recurrence in patients with lung adenocarcinoma.

原文	英語
主出版物標題	MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
發行者	Chemical and Biological Microsystems Society
頁面	1141-1142
頁數	2
ISBN（電子）	9781733419017
出版狀態	已出版 - 2020
對外發佈	是
事件	24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online 持續時間: 04 10 2020 → 09 10 2020

出版系列

名字	MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference	24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
城市	Virtual, Online
期間	04/10/20 → 09/10/20

文獻附註

Publisher Copyright:
© 2020 CBMS-0001

UN SDG

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其它文件與鏈接

Link to publication in Scopus

引用此

Hsu, C. J., Kan, Y. C., Lee, C. W., Wu, J. K., Lee, K. Y., Feng, P. H., Chang, W. C., & Tseng, F. G. (2020). Saca chip enabled circulating tumor cell clusters phenotyping for cancer immunotherapy response monitoring. 於 MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (頁 1141-1142). (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.

Hsu, Chun Jieh ; Kan, Yu Chia ; Lee, Chun Wei 等. / Saca chip enabled circulating tumor cell clusters phenotyping for cancer immunotherapy response monitoring. MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2020. 頁 1141-1142 (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

@inproceedings{1b5f080e6e3b43a0977fe34465b3a2c2,

title = "Saca chip enabled circulating tumor cell clusters phenotyping for cancer immunotherapy response monitoring",

abstract = "In the present study, we indicated that the detection of specific subtypes of circulating tumor microemboli (CTM) in post-operative patients could help predict cancer recurrence. By using conventional strategies for detection of non-small-cell lung cancer (NSCLC) circulating tumor cells, is significantly limited due to inherently heterogeneous and dynamic expression of EpCAM, and degradation of cytokeratins during epithelial-tomesenchymal transition. These lead to non-negligible false negative detection of “uncapturable and invisible” single CTCs. To solve the problem, we investigated the clinical significance of CTM subtypes, including single CTCs, multi-CTCs cluster, and WBC-CTCs cluster on SACA chip for studying cancer metastasis and recurrence in patients with lung adenocarcinoma.",

keywords = "Circulating Tumor Cell Clusters, Immunotherapy, Non-small-cell lung cancer (NSCLC)",

author = "Hsu, {Chun Jieh} and Kan, {Yu Chia} and Lee, {Chun Wei} and Wu, {Jen Kuei} and Lee, {Kang Yun} and Feng, {Po Hao} and Chang, {Wei Chiao} and Tseng, {Fan Gang}",

note = "Publisher Copyright: {\textcopyright} 2020 CBMS-0001; 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 ; Conference date: 04-10-2020 Through 09-10-2020",

year = "2020",

language = "英语",

series = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "Chemical and Biological Microsystems Society",

pages = "1141--1142",

booktitle = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

}

Hsu, CJ, Kan, YC, Lee, CW, Wu, JK, Lee, KY, Feng, PH, Chang, WC & Tseng, FG 2020, Saca chip enabled circulating tumor cell clusters phenotyping for cancer immunotherapy response monitoring. 於 MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, 頁 1141-1142, 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020, Virtual, Online, 04/10/20.

Saca chip enabled circulating tumor cell clusters phenotyping for cancer immunotherapy response monitoring. / Hsu, Chun Jieh; Kan, Yu Chia; Lee, Chun Wei 等.
MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2020. p. 1141-1142 (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

研究成果: 圖書/報告稿件的類型 › 會議稿件 › 同行評審

TY - GEN

T1 - Saca chip enabled circulating tumor cell clusters phenotyping for cancer immunotherapy response monitoring

AU - Hsu, Chun Jieh

AU - Kan, Yu Chia

AU - Lee, Chun Wei

AU - Wu, Jen Kuei

AU - Lee, Kang Yun

AU - Feng, Po Hao

AU - Chang, Wei Chiao

AU - Tseng, Fan Gang

PY - 2020

Y1 - 2020

N2 - In the present study, we indicated that the detection of specific subtypes of circulating tumor microemboli (CTM) in post-operative patients could help predict cancer recurrence. By using conventional strategies for detection of non-small-cell lung cancer (NSCLC) circulating tumor cells, is significantly limited due to inherently heterogeneous and dynamic expression of EpCAM, and degradation of cytokeratins during epithelial-tomesenchymal transition. These lead to non-negligible false negative detection of “uncapturable and invisible” single CTCs. To solve the problem, we investigated the clinical significance of CTM subtypes, including single CTCs, multi-CTCs cluster, and WBC-CTCs cluster on SACA chip for studying cancer metastasis and recurrence in patients with lung adenocarcinoma.

AB - In the present study, we indicated that the detection of specific subtypes of circulating tumor microemboli (CTM) in post-operative patients could help predict cancer recurrence. By using conventional strategies for detection of non-small-cell lung cancer (NSCLC) circulating tumor cells, is significantly limited due to inherently heterogeneous and dynamic expression of EpCAM, and degradation of cytokeratins during epithelial-tomesenchymal transition. These lead to non-negligible false negative detection of “uncapturable and invisible” single CTCs. To solve the problem, we investigated the clinical significance of CTM subtypes, including single CTCs, multi-CTCs cluster, and WBC-CTCs cluster on SACA chip for studying cancer metastasis and recurrence in patients with lung adenocarcinoma.

KW - Circulating Tumor Cell Clusters

KW - Immunotherapy

KW - Non-small-cell lung cancer (NSCLC)

UR - http://www.scopus.com/inward/record.url?scp=85098250787&partnerID=8YFLogxK

M3 - 会议稿件

AN - SCOPUS:85098250787

T3 - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

SP - 1141

EP - 1142

BT - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

T2 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020

Y2 - 4 October 2020 through 9 October 2020

ER -

Hsu CJ, Kan YC, Lee CW, Wu JK, Lee KY, Feng PH 等. Saca chip enabled circulating tumor cell clusters phenotyping for cancer immunotherapy response monitoring. 於 MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2020. p. 1141-1142. (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Saca chip enabled circulating tumor cell clusters phenotyping for cancer immunotherapy response monitoring

摘要

出版系列

Conference

文獻附註

UN SDG

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