Secondary metabolites from the root of Ehretia longiflora and their biological activities

Yu Chieh Chien; Chu Hung Lin; Michael Y. Chiang; Hsun Shuo Chang; Chang Hui Liao; Ih Sheng Chen; Chien Fang Peng; Ian Lih Tsai

doi:10.1016/j.phytochem.2012.04.013

Secondary metabolites from the root of Ehretia longiflora and their biological activities

Yu Chieh Chien
, Chu Hung Lin
, Michael Y. Chiang
, Hsun Shuo Chang
, Chang Hui Liao
, Ih Sheng Chen
, Chien Fang Peng
, Ian Lih Tsai^*

^*此作品的通信作者

中醫學系(含學士班、天然藥物、傳統中醫藥碩士班)

Kaohsiung Medical University
National Sun Yat-sen University

研究成果: 期刊稿件 › 文章 › 同行評審

33 引文斯高帕斯（Scopus）

摘要

Bioassay-guided fractionation of the methanolic extract of the root of Ehretia longiflora (Boraginaceae) afforded eight compounds, ehretiquinone (1), ehretiolide (2), ehreticoumarin (3), ehretilactone A (4), ehretilactone B (5), ehretiamide (6), ehretine (7), and ehretiate (8), together with 12 known compounds (9-20). The relative configuration of 1 was determined by single crystal X-ray diffraction. Among the isolates, 1 and prenylhydroquinone (14) showed antitubercular activity against Mycobacterium tuberculosis strain H37Rv with MIC values of 25.0 and 26.2 μg/mL, respectively. Moreover, 1 exhibited inhibitory effects on N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide production, with IC ₅₀ value of 0.36 ± 0.03 μM.

原文	英語
頁（從 - 到）	50-57
頁數	8
期刊	Phytochemistry
卷	80
DOIs	https://doi.org/10.1016/j.phytochem.2012.04.013
出版狀態	已出版 - 08 2012

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@article{18c49a8390224355b16b26916f03d4a3,

title = "Secondary metabolites from the root of Ehretia longiflora and their biological activities",

abstract = "Bioassay-guided fractionation of the methanolic extract of the root of Ehretia longiflora (Boraginaceae) afforded eight compounds, ehretiquinone (1), ehretiolide (2), ehreticoumarin (3), ehretilactone A (4), ehretilactone B (5), ehretiamide (6), ehretine (7), and ehretiate (8), together with 12 known compounds (9-20). The relative configuration of 1 was determined by single crystal X-ray diffraction. Among the isolates, 1 and prenylhydroquinone (14) showed antitubercular activity against Mycobacterium tuberculosis strain H37Rv with MIC values of 25.0 and 26.2 μg/mL, respectively. Moreover, 1 exhibited inhibitory effects on N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide production, with IC 50 value of 0.36 ± 0.03 μM.",

keywords = "Anti-inflammatory activity, Antitubercular activity, Boraginaceae, Ehretia longiflora, Root",

author = "Chien, \{Yu Chieh\} and Lin, \{Chu Hung\} and Chiang, \{Michael Y.\} and Chang, \{Hsun Shuo\} and Liao, \{Chang Hui\} and Chen, \{Ih Sheng\} and Peng, \{Chien Fang\} and Tsai, \{Ian Lih\}",

year = "2012",

month = aug,

doi = "10.1016/j.phytochem.2012.04.013",

language = "英语",

volume = "80",

pages = "50--57",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Secondary metabolites from the root of Ehretia longiflora and their biological activities

AU - Chien, Yu Chieh

AU - Lin, Chu Hung

AU - Chiang, Michael Y.

AU - Chang, Hsun Shuo

AU - Liao, Chang Hui

AU - Chen, Ih Sheng

AU - Peng, Chien Fang

AU - Tsai, Ian Lih

PY - 2012/8

Y1 - 2012/8

N2 - Bioassay-guided fractionation of the methanolic extract of the root of Ehretia longiflora (Boraginaceae) afforded eight compounds, ehretiquinone (1), ehretiolide (2), ehreticoumarin (3), ehretilactone A (4), ehretilactone B (5), ehretiamide (6), ehretine (7), and ehretiate (8), together with 12 known compounds (9-20). The relative configuration of 1 was determined by single crystal X-ray diffraction. Among the isolates, 1 and prenylhydroquinone (14) showed antitubercular activity against Mycobacterium tuberculosis strain H37Rv with MIC values of 25.0 and 26.2 μg/mL, respectively. Moreover, 1 exhibited inhibitory effects on N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide production, with IC 50 value of 0.36 ± 0.03 μM.

AB - Bioassay-guided fractionation of the methanolic extract of the root of Ehretia longiflora (Boraginaceae) afforded eight compounds, ehretiquinone (1), ehretiolide (2), ehreticoumarin (3), ehretilactone A (4), ehretilactone B (5), ehretiamide (6), ehretine (7), and ehretiate (8), together with 12 known compounds (9-20). The relative configuration of 1 was determined by single crystal X-ray diffraction. Among the isolates, 1 and prenylhydroquinone (14) showed antitubercular activity against Mycobacterium tuberculosis strain H37Rv with MIC values of 25.0 and 26.2 μg/mL, respectively. Moreover, 1 exhibited inhibitory effects on N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide production, with IC 50 value of 0.36 ± 0.03 μM.

KW - Anti-inflammatory activity

KW - Antitubercular activity

KW - Boraginaceae

KW - Ehretia longiflora

KW - Root

UR - https://www.scopus.com/pages/publications/84863629596

U2 - 10.1016/j.phytochem.2012.04.013

DO - 10.1016/j.phytochem.2012.04.013

M3 - 文章

C2 - 22626966

AN - SCOPUS:84863629596

SN - 0031-9422

VL - 80

SP - 50

EP - 57

JO - Phytochemistry

JF - Phytochemistry

ER -

Secondary metabolites from the root of Ehretia longiflora and their biological activities

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