Sensitivity enhancement based on application of multi-pass interferometry in phase-sensitive surface plasmon resonance biosensor

H. P. Ho*, W. Yuan, C. L. Wong, S. Y. Wu, Y. K. Suen, S. K. Kong, Chinlon Lin

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

61 引文 斯高帕斯(Scopus)

摘要

A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the interferometer so that the interrogating optical beam will traverse the sensor surface infinite number of times. Experimental interferometers based on the Michelson and Fabry-Perot configurations have been employed to experimentally verify this amplification effect when they were compared with Mach-Zehnder configuration, results obtained from salt-water mixtures, antibody-antigen, and protein-DNA binding reaction confirmed the expected phase measurement enhancement, thus leading to the possibility of direct detection of small sized bio-molecules using SPR.

原文英語
頁(從 - 到)491-496
頁數6
期刊Optics Communications
275
發行號2
DOIs
出版狀態已出版 - 15 07 2007
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