摘要
A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the interferometer so that the interrogating optical beam will traverse the sensor surface infinite number of times. Experimental interferometers based on the Michelson and Fabry-Perot configurations have been employed to experimentally verify this amplification effect when they were compared with Mach-Zehnder configuration, results obtained from salt-water mixtures, antibody-antigen, and protein-DNA binding reaction confirmed the expected phase measurement enhancement, thus leading to the possibility of direct detection of small sized bio-molecules using SPR.
原文 | 英語 |
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頁(從 - 到) | 491-496 |
頁數 | 6 |
期刊 | Optics Communications |
卷 | 275 |
發行號 | 2 |
DOIs | |
出版狀態 | 已出版 - 15 07 2007 |
對外發佈 | 是 |