Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils

Jih Jung Chen; Cheng Shuan Tsai; Tsong Long Hwang; Po Chuen Shieh; Jinn Fen Chen; Ping Jyun Sung

doi:10.1016/j.foodchem.2009.07.060

Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils

Jih Jung Chen^*
, Cheng Shuan Tsai
, Tsong Long Hwang
, Po Chuen Shieh
, Jinn Fen Chen
, Ping Jyun Sung

^*此作品的通信作者

中醫學系(含學士班、天然藥物、傳統中醫藥碩士班)

Tajen University
Taitung District Agricultural Research and Extension Station
National Museum of Marine Biology and Aquarium, Taiwan

研究成果: 期刊稿件 › 文章 › 同行評審

61 引文斯高帕斯（Scopus）

摘要

Six new sesquiterpenes, curculonone A (1), curculonone B (2), curculonone C (3), curculonone D (4), 6α-hydroxycurcumanolide A (5), and 1,10-dehydro-10-deoxy-9-oxozedoarondiol (6), have been isolated from the rhizome of Curcuma longa, together with 19 known compounds. The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 2, 5, 12, 15, 16, and 23 exhibited inhibition (IC₅₀ ≤ 18.22 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 5, 12-16, and 23 inhibited fMLP/CB-induced elastase release with IC₅₀ values ≤ 14.28 μM.

原文	英語
頁（從 - 到）	974-980
頁數	7
期刊	Food Chemistry
卷	119
發行號	3
DOIs	https://doi.org/10.1016/j.foodchem.2009.07.060
出版狀態	已出版 - 01 04 2010

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10.1016/j.foodchem.2009.07.060

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@article{6b08b827a09347629e902aa640878862,

title = "Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils",

abstract = "Six new sesquiterpenes, curculonone A (1), curculonone B (2), curculonone C (3), curculonone D (4), 6α-hydroxycurcumanolide A (5), and 1,10-dehydro-10-deoxy-9-oxozedoarondiol (6), have been isolated from the rhizome of Curcuma longa, together with 19 known compounds. The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 2, 5, 12, 15, 16, and 23 exhibited inhibition (IC50 ≤ 18.22 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 5, 12-16, and 23 inhibited fMLP/CB-induced elastase release with IC50 values ≤ 14.28 μM.",

keywords = "Curcuma longa, Inhibitory activity on neutrophil pro-inflammatory responses, Sesquiterpenes, Structure elucidation, Zingiberaceae",

author = "Chen, \{Jih Jung\} and Tsai, \{Cheng Shuan\} and Hwang, \{Tsong Long\} and Shieh, \{Po Chuen\} and Chen, \{Jinn Fen\} and Sung, \{Ping Jyun\}",

year = "2010",

month = apr,

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doi = "10.1016/j.foodchem.2009.07.060",

language = "英语",

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TY - JOUR

T1 - Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils

AU - Chen, Jih Jung

AU - Tsai, Cheng Shuan

AU - Hwang, Tsong Long

AU - Shieh, Po Chuen

AU - Chen, Jinn Fen

AU - Sung, Ping Jyun

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Six new sesquiterpenes, curculonone A (1), curculonone B (2), curculonone C (3), curculonone D (4), 6α-hydroxycurcumanolide A (5), and 1,10-dehydro-10-deoxy-9-oxozedoarondiol (6), have been isolated from the rhizome of Curcuma longa, together with 19 known compounds. The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 2, 5, 12, 15, 16, and 23 exhibited inhibition (IC50 ≤ 18.22 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 5, 12-16, and 23 inhibited fMLP/CB-induced elastase release with IC50 values ≤ 14.28 μM.

AB - Six new sesquiterpenes, curculonone A (1), curculonone B (2), curculonone C (3), curculonone D (4), 6α-hydroxycurcumanolide A (5), and 1,10-dehydro-10-deoxy-9-oxozedoarondiol (6), have been isolated from the rhizome of Curcuma longa, together with 19 known compounds. The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 2, 5, 12, 15, 16, and 23 exhibited inhibition (IC50 ≤ 18.22 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 5, 12-16, and 23 inhibited fMLP/CB-induced elastase release with IC50 values ≤ 14.28 μM.

KW - Curcuma longa

KW - Inhibitory activity on neutrophil pro-inflammatory responses

KW - Sesquiterpenes

KW - Structure elucidation

KW - Zingiberaceae

UR - https://www.scopus.com/pages/publications/70449094675

U2 - 10.1016/j.foodchem.2009.07.060

DO - 10.1016/j.foodchem.2009.07.060

M3 - 文章

AN - SCOPUS:70449094675

SN - 0308-8146

VL - 119

SP - 974

EP - 980

JO - Food Chemistry

JF - Food Chemistry

IS - 3

ER -

Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils

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