Soluble Dectin-1 as a tool to detect β-glucans

Lisa M. Graham, S. Vicky Tsoni, Janet A. Willment, David L. Williams, Philip R. Taylor, Siamon Gordon, Kevin Dennehy, Gordon D. Brown*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

101 引文 斯高帕斯(Scopus)

摘要

β-Glucans are structural components of fungal cell walls which are involved in the immune recognition of fungal pathogens and possess beneficial immunomodulatory activities in isolated form. Here we have developed a soluble chimeric form of the major mammalian β-glucan receptor, Dectin-1, and demonstrate its application for the detection and characterisation of soluble and insoluble β-glucans, including fungal particles, using ELISA, flow cytometric and fluorescence-based microscopy assays.

原文英語
頁(從 - 到)164-169
頁數6
期刊Journal of Immunological Methods
314
發行號1-2
DOIs
出版狀態已出版 - 31 07 2006
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