Steroidal and α-tocopherylhydroquinone glycosides from two soft corals Cladiella hirsuta and Sinularia nanolobata

Chih Hua Chao; Tzu Zin Huang; Chia Yun Wu; Bo Wei Chen; Chiung Yao Huang; Tsong Long Hwang; Chang Feng Dai; Jyh Horng Sheu

doi:10.1039/c5ra13436f

Steroidal and α-tocopherylhydroquinone glycosides from two soft corals Cladiella hirsuta and Sinularia nanolobata

Chih Hua Chao, Tzu Zin Huang, Chia Yun Wu, Bo Wei Chen, Chiung Yao Huang, Tsong Long Hwang, Chang Feng Dai, Jyh Horng Sheu^*

^*此作品的通信作者

中醫學系(含學士班、天然藥物、傳統中醫藥碩士班)

研究成果: 期刊稿件 › 文章 › 同行評審

16 引文斯高帕斯（Scopus）

摘要

Two new pregnane glycosides, hirsutosterosides A and B (1 and 2), as well as two new α-tocopherylhydroquinone glycosides, cladophenol glycosides A and B (3 and 4) were isolated from a soft coral Cladiella hirsuta. In addition, a new steroidal glycoside, lobatasteroside A (5) along with six known steroids (6-11), were discovered from the other soft coral Sinularia nanolobata. Their structures were elucidated by extensive spectroscopic analysis. Cytotoxicities of the isolates against a limited panel of cancer cell lines were reported. The inhibitory activities for superoxide anion generation and elastase release for these compounds were also examined to evaluate the anti-inflammatory potential.

原文	英語
頁（從 - 到）	74256-74262
頁數	7
期刊	RSC Advances
卷	5
發行號	91
DOIs	https://doi.org/10.1039/c5ra13436f
出版狀態	已出版 - 24 08 2015

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© 2015 The Royal Society of Chemistry.

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title = "Steroidal and α-tocopherylhydroquinone glycosides from two soft corals Cladiella hirsuta and Sinularia nanolobata",

abstract = "Two new pregnane glycosides, hirsutosterosides A and B (1 and 2), as well as two new α-tocopherylhydroquinone glycosides, cladophenol glycosides A and B (3 and 4) were isolated from a soft coral Cladiella hirsuta. In addition, a new steroidal glycoside, lobatasteroside A (5) along with six known steroids (6-11), were discovered from the other soft coral Sinularia nanolobata. Their structures were elucidated by extensive spectroscopic analysis. Cytotoxicities of the isolates against a limited panel of cancer cell lines were reported. The inhibitory activities for superoxide anion generation and elastase release for these compounds were also examined to evaluate the anti-inflammatory potential.",

author = "Chao, {Chih Hua} and Huang, {Tzu Zin} and Wu, {Chia Yun} and Chen, {Bo Wei} and Huang, {Chiung Yao} and Hwang, {Tsong Long} and Dai, {Chang Feng} and Sheu, {Jyh Horng}",

note = "Publisher Copyright: {\textcopyright} 2015 The Royal Society of Chemistry.",

year = "2015",

month = aug,

day = "24",

doi = "10.1039/c5ra13436f",

language = "英语",

volume = "5",

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T1 - Steroidal and α-tocopherylhydroquinone glycosides from two soft corals Cladiella hirsuta and Sinularia nanolobata

AU - Chao, Chih Hua

AU - Huang, Tzu Zin

AU - Wu, Chia Yun

AU - Chen, Bo Wei

AU - Huang, Chiung Yao

AU - Hwang, Tsong Long

AU - Dai, Chang Feng

AU - Sheu, Jyh Horng

PY - 2015/8/24

Y1 - 2015/8/24

N2 - Two new pregnane glycosides, hirsutosterosides A and B (1 and 2), as well as two new α-tocopherylhydroquinone glycosides, cladophenol glycosides A and B (3 and 4) were isolated from a soft coral Cladiella hirsuta. In addition, a new steroidal glycoside, lobatasteroside A (5) along with six known steroids (6-11), were discovered from the other soft coral Sinularia nanolobata. Their structures were elucidated by extensive spectroscopic analysis. Cytotoxicities of the isolates against a limited panel of cancer cell lines were reported. The inhibitory activities for superoxide anion generation and elastase release for these compounds were also examined to evaluate the anti-inflammatory potential.

AB - Two new pregnane glycosides, hirsutosterosides A and B (1 and 2), as well as two new α-tocopherylhydroquinone glycosides, cladophenol glycosides A and B (3 and 4) were isolated from a soft coral Cladiella hirsuta. In addition, a new steroidal glycoside, lobatasteroside A (5) along with six known steroids (6-11), were discovered from the other soft coral Sinularia nanolobata. Their structures were elucidated by extensive spectroscopic analysis. Cytotoxicities of the isolates against a limited panel of cancer cell lines were reported. The inhibitory activities for superoxide anion generation and elastase release for these compounds were also examined to evaluate the anti-inflammatory potential.

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U2 - 10.1039/c5ra13436f

DO - 10.1039/c5ra13436f

M3 - 文章

AN - SCOPUS:84941236837

SN - 2046-2069

VL - 5

SP - 74256

EP - 74262

JO - RSC Advances

JF - RSC Advances

IS - 91

ER -

Steroidal and α-tocopherylhydroquinone glycosides from two soft corals Cladiella hirsuta and Sinularia nanolobata

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