Successful pregnancy after preimplantation genetic diagnosis in a female with Robertsonian translocation

Yueh Chao Wu, Chun Kai Chen, Hong Yuan Huang*, Chi Ju Chou, Yung Kuei Soong

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

Preimplantation genetic diagnosis (PGD) is an alternative option for couples with chromosome abnormalities. A 34-year-old woman with balanced Robertsonian translocation [ (45, XX, der(13; 14) (q10; q10) ] requested PGD due to recurrent spontaneous abortion. Embryos of good quality were biopsied on day 3 post-oocyte retrieval. The aspirated blastomeres were fixed and analyzed using fluorescence in situ hybridization. In the first cycle, 2 unaffected embryos were transferred back without success. No unaffected embryo was available in the second cycle. On day 5 in the third cycle, 2 unaffected embryos were transferred resulting in a twin pregnancy. Amniocentesis confirmed the diagnosis. At the gestational age of 35 weeks, 2 healthy girls were born via cesarean section. Postnatal physical examination found no evidence of major abnormalities.

原文英語
頁(從 - 到)637-639
頁數3
期刊Journal of the Formosan Medical Association
103
發行號8
出版狀態已出版 - 08 2004
對外發佈

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