Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development

Chia Hung Wang; Shiou Ting Li; Tzu Lung Lin; Yang Yu Cheng; Tsung Hsien Sun; Jin Town Wang; Ting Jen R. Cheng; Kwok Kong Tony Mong; Chi Huey Wong; Chung Yi Wu

doi:10.1002/anie.201302540

Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development

Chia Hung Wang
, Shiou Ting Li
, Tzu Lung Lin
, Yang Yu Cheng
, Tsung Hsien Sun
, Jin Town Wang
, Ting Jen R. Cheng
, Kwok Kong Tony Mong
, Chi Huey Wong
, Chung Yi Wu^*

^*此作品的通信作者

Academia Sinica - Genomics Research Center
National Yang Ming Chiao Tung University
National Taiwan University

研究成果: 期刊稿件 › 文章 › 同行評審

57 引文斯高帕斯（Scopus）

摘要

Sweetening the deal: N.meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide-protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.

原文	英語
頁（從 - 到）	9157-9161
頁數	5
期刊	Angewandte Chemie - International Edition
卷	52
發行號	35
DOIs	https://doi.org/10.1002/anie.201302540
出版狀態	已出版 - 26 08 2013
對外發佈	是

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Wang, C. H., Li, S. T., Lin, T. L., Cheng, Y. Y., Sun, T. H., Wang, J. T., Cheng, T. J. R., Mong, K. K. T., Wong, C. H., & Wu, C. Y. (2013). Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development. Angewandte Chemie - International Edition, 52(35), 9157-9161. https://doi.org/10.1002/anie.201302540

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abstract = "Sweetening the deal: N.meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide-protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.",

keywords = "N. meningitidis, bactericidal, oligosaccharides, total synthesis, vaccine",

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AU - Li, Shiou Ting

AU - Lin, Tzu Lung

AU - Cheng, Yang Yu

AU - Sun, Tsung Hsien

AU - Wang, Jin Town

AU - Cheng, Ting Jen R.

AU - Mong, Kwok Kong Tony

AU - Wong, Chi Huey

AU - Wu, Chung Yi

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AB - Sweetening the deal: N.meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide-protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.

KW - N. meningitidis

KW - bactericidal

KW - oligosaccharides

KW - total synthesis

KW - vaccine

UR - https://www.scopus.com/pages/publications/84883010128

U2 - 10.1002/anie.201302540

DO - 10.1002/anie.201302540

M3 - 文章

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AN - SCOPUS:84883010128

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 35

ER -

Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development

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