TY - JOUR
T1 - Targeting of AID-mediated sequence diversification to immunoglobulin genes
AU - Kothapalli, Naga Rama
AU - Fugmann, Sebastian D.
PY - 2011/4
Y1 - 2011/4
N2 - Activation-induced cytidine deaminase (AID) is a key enzyme for antibody-mediated immune responses. Antibodies are encoded by the immunoglobulin genes and AID acts as a transcription-dependent DNA mutator on these genes to improve antibody affinity and effector functions. An emerging theme in field is that many transcribed genes are potential targets of AID, presenting an obvious danger to genomic integrity. Thus there are mechanisms in place to ensure that mutagenic outcomes of AID activity are specifically restricted to the immunoglobulin loci. Cis-regulatory targeting elements mediate this effect and their mode of action is probably a combination of immunoglobulin gene specific activation of AID and a perversion of faithful DNA repair towards error-prone outcomes.
AB - Activation-induced cytidine deaminase (AID) is a key enzyme for antibody-mediated immune responses. Antibodies are encoded by the immunoglobulin genes and AID acts as a transcription-dependent DNA mutator on these genes to improve antibody affinity and effector functions. An emerging theme in field is that many transcribed genes are potential targets of AID, presenting an obvious danger to genomic integrity. Thus there are mechanisms in place to ensure that mutagenic outcomes of AID activity are specifically restricted to the immunoglobulin loci. Cis-regulatory targeting elements mediate this effect and their mode of action is probably a combination of immunoglobulin gene specific activation of AID and a perversion of faithful DNA repair towards error-prone outcomes.
UR - http://www.scopus.com/inward/record.url?scp=79953100396&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2010.12.009
DO - 10.1016/j.coi.2010.12.009
M3 - 文章
C2 - 21295456
AN - SCOPUS:79953100396
SN - 0952-7915
VL - 23
SP - 184
EP - 189
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 2
ER -