The Cellular and Molecular Network of IL-4 and IL-13

Fernando O. Martinez Estrada; Siamon Gordon

doi:10.1016/B978-0-12-374279-7.10012-8

The Cellular and Molecular Network of IL-4 and IL-13

Fernando O. Martinez Estrada^*
, Siamon Gordon

^*此作品的通信作者

University of Oxford

研究成果: 圖書/報告稿件的類型 › 章節 › 同行評審

摘要

Interleukin (IL)-4 and IL-13 control the phenotype of a variety of cells in health and disease. Their receptor system, signaling cascades, and functional properties have gained clarity in the past 30. years. In this article, we give an overview of the production, sensing, and effects of both cytokines concluding with a discussion of the therapeutic potential of IL-4 and IL-13 inhibition or supplementation in patients.

原文	英語
主出版物標題	Molecular Immunology
發行者	Elsevier Inc.
頁面	519-524
頁數	6
卷	2
ISBN（列印）	9780080921525
DOIs	https://doi.org/10.1016/B978-0-12-374279-7.10012-8
出版狀態	已出版 - 27 04 2016
對外發佈	是

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© 2016 Elsevier Ltd All rights reserved.

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10.1016/B978-0-12-374279-7.10012-8

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KW - Allergy

KW - Alternative activation

KW - Biologics

KW - Fibrosis

KW - IL-13

KW - IL-4

KW - Mast cells

KW - Signaling

KW - Th2 cells

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The Cellular and Molecular Network of IL-4 and IL-13

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