The cytokine genes of Oncorhynchus masou formosanus include a defective interleukin-4/13A gene

Ying Hsuan Yen, De Yu Zheng, Shu Yuan Yang, Jin Chywan Gwo, Sebastian D. Fugmann*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

摘要

Oncorhynchus masou formosanus (Formosa landlocked salmon) is a critically endangered salmonid fish endemic to Taiwan. To begin to understand how its drastic change in lifestyle from anadromous to exclusively river-dwelling is reflected in its immune genes, we characterized the genes encoding six cytokines (IL-2A, IL-2B, IL-4/13A, IL-4/13B1, IL-4/13B2, and IL-17A/F2a) important for T cell responses as no genomic data is available for this fish. Interestingly, all genes appeared homozygous indicative of a genetic bottleneck. The IL2 and IL17A/F2a genes and their products are highly similar to their characterized homologs in Oncorhynchus mykiss (rainbow trout) and other salmonid fish. Two notable differences were observed in IL4/13 family important for type 2 immune responses. First, O. m. formosanus carries not only one but two genes encoding IL-4/13B1 proteins and expansions of these genes are present in other salmonid fish. Second, the OmfoIL4/13A gene carries a 228 bp deletion that results in a premature stop codon and hence a non-functional IL-4/13A cytokine. This suggests a reduced ability for T cell responses against parasitic infections in this species.

原文英語
文章編號105156
頁(從 - 到)105156 - 105166
頁數11
期刊Developmental and Comparative Immunology
155
DOIs
出版狀態已出版 - 06 2024

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